A Plasma-Polymerized Film for Surface Plasmon Resonance Immunosensing

Runa Nakamura, Hitoshi Muguruma, Kazunori Ikebukuro, Satoshi Sasaki, Ryohei Nagata, Isao Karube, Henrik Pedersen

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)


We propose a novel ethylenediamine plasma-polymerized film matrix that is deposited on gold surfaces for use in surface plasmon resonance immunosensing. The films formed on the gold surfaces are extremely thin (∼100 nm), are homogeneous, demonstrate good adhesion, have a flat profile, and incorporate amino groups to introduce a chemical functionality. A sensor chip made with the film has many advantages when compared with conventionally used designs such as carboxylated dextran hydrogels. For example, a sensor chip made with the film shows a better sensor response than a conventional design partly because antibodies are densely and two-dimensionally immobilized onto the surface of the plasma-polymerized film.

Original languageEnglish
Pages (from-to)4649-4652
Number of pages4
JournalAnalytical Chemistry
Issue number22
Publication statusPublished - 1997 Nov 15
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry


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