TY - GEN
T1 - A synthetic replica having surface morphology of decellularized tissue regulated orientation and shape of cells
AU - Kimura, Tsuvoshi
AU - Kobayashi, Mako
AU - Hashimoto, Yoshihide
AU - Fujisato, Toshiya
AU - Nakamura, Naoko
AU - Kisliida, Akio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Decellularized tissues, which are extracellular matrix assembly prepared from living tissue, are tried to apply for regenerative medicine and to be used as biomaterials because of the good biocompatibility. Recently, many researchers are challenging to resolve its mechanism, but it is still unclear. Previously, our group also reported that decellularized tissues were prepared by high hydrostatic pressure (HHP) technology and they showed good biocompatibility [1]. Especially, decellularized aorta showed good patency and early endothelialization for in vivo vascular replacement [2].One possible reason is that HHP decellularized luminal surface remains the similar morphology to native aortic lumenal surface. In this study, we investigated the surface morphology of aortic lumen prepared by various decellularization methods using HHP and SDS, and synthetic replicas were prepared by a transferring method using poly(dimethyl siloxane) (PDMS). The endothelial cell behavior on them was investigated (Figure 1).
AB - Decellularized tissues, which are extracellular matrix assembly prepared from living tissue, are tried to apply for regenerative medicine and to be used as biomaterials because of the good biocompatibility. Recently, many researchers are challenging to resolve its mechanism, but it is still unclear. Previously, our group also reported that decellularized tissues were prepared by high hydrostatic pressure (HHP) technology and they showed good biocompatibility [1]. Especially, decellularized aorta showed good patency and early endothelialization for in vivo vascular replacement [2].One possible reason is that HHP decellularized luminal surface remains the similar morphology to native aortic lumenal surface. In this study, we investigated the surface morphology of aortic lumen prepared by various decellularization methods using HHP and SDS, and synthetic replicas were prepared by a transferring method using poly(dimethyl siloxane) (PDMS). The endothelial cell behavior on them was investigated (Figure 1).
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M3 - Conference contribution
AN - SCOPUS:85065388149
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -