Adaptive and quantitative reconstruction algorithm for photoacoustic tomography

Shuhui Bu, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina, Kazuhiko Fukutani, Yasuhiro Someda, Yasufumi Asao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)


Photoacoustic (PA) tomography is a rapidly developing imaging modality which can provide high contrast and spatial-resolution images of light absorption distribution in tissue. However, the quantitative reconstruction of absorption distribution is still a challenge. In this study, we propose an adaptive and quantitative reconstruction algorithm for reducing amplification of noises and artifacts in deep position due to light fluence compensation. In this method, the quantitative processing is integrated into the iterative reconstruction, and absorption coefficient distribution is iteratively updated. At each iteration step, the residual is calculated from detected PA signals and the signals calculated from a forward model by using the initial pressure which is calculated from the production of voxel value and the light fluence. By minimizing the residual, the reconstructed values are converged to the true absorption coefficient distributions. Since this method uses a global optimized compensation, better CNR can be obtained. The results of simulation and phantom experiment indicate that the proposed method provide better CNR at deep region. We expect that the capability of increasing imaging depth will broaden clinical applications.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2011
Publication statusPublished - 2011
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, United States
Duration: 2011 Jan 232011 Jan 25

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2011
Country/TerritoryUnited States
CitySan Francisco, CA


  • Iterative reconstruction
  • Model-based reconstruction
  • Photoacoustic tomography
  • Quantitative reconstruction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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