Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.

Takashi Iguchi; Hirohumi Ishikawa; Hiroharu Matumoto; Mamoru Mizuno; Kohtaro Goto; Keita Hamasaki

doi:10.1093/nass/49.1.169

Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.

Takashi Iguchi, Hirohumi Ishikawa, Hiroharu Matumoto, Mamoru Mizuno, Kohtaro Goto, Keita Hamasaki

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Amino disaccharides having an alpha-(1-->4) linkage or a beta-(1-->4) linkage have been prepared as the mimics of amino glycoside antibiotics and their inhibition for HIV-1 TAR-Tat were examined. The compound having alpha-(1-->4) linkage denotes better inhibition for TAR-Tat than that of the one having beta-(1-->4).

Original language	English
Pages (from-to)	169-170
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	49
DOIs	https://doi.org/10.1093/nass/49.1.169
Publication status	Published - 2005

ASJC Scopus subject areas

Medicine(all)

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abstract = "Amino disaccharides having an alpha-(1-->4) linkage or a beta-(1-->4) linkage have been prepared as the mimics of amino glycoside antibiotics and their inhibition for HIV-1 TAR-Tat were examined. The compound having alpha-(1-->4) linkage denotes better inhibition for TAR-Tat than that of the one having beta-(1-->4).",

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T1 - Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.

AU - Iguchi, Takashi

AU - Ishikawa, Hirohumi

AU - Matumoto, Hiroharu

AU - Mizuno, Mamoru

AU - Goto, Kohtaro

AU - Hamasaki, Keita

PY - 2005

Y1 - 2005

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ER -

Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.

Abstract

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