TY - GEN
T1 - Applicability of photoacoustic microscopy to quantitative photoaging evaluation
AU - Hattori, Hiroki
AU - Namita, Takeshi
AU - Kondo, Kengo
AU - Yamakawa, Makoto
AU - Shiina, Tsuyoshi
N1 - Funding Information:
This work was partly supported by the Impulsing Paradigm Change through Disrupt Technologies (ImPACT) program of the cabinet office of Japan and the Incubation Program of Kyoto University.
Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2021
Y1 - 2021
N2 - Skin aging caused by ultraviolet light exposure is one of the serious problems from the viewpoint of beauty and healthcare. This is because ultraviolet light can cause age spot, wrinkles, at the worst case, skin cancer and so on. To evaluate skin aging, various modalities are being used, such as histopathological diagnosis, optical imaging (e.g. optical coherence tomography (OCT), second harmonic tomography (SHG)) and ultrasound examination (B-mode imaging). However, they have disadvantages in terms of invasiveness, penetration depth and tissue specificity, respectively. To overcome these defects, photoacoustic imaging (PAI), a novel modality was used in this work. This modality can portray differences of tissue characteristics non-invasively. In this work, human skin tissues in various degrees of photoaging (8 subjects, 2 kind of site each) were measured by using acoustic resolution photoacoustic microscopy (AR-PAM) to verify the feasibility of quantitative skin aging evaluation with PA technique. The effects of photoaging progress on the signal intensity were investigated. The results demonstrated that the PA signal from the dermis increases as photoaging progresses. These analyses demonstrate the feasibility of quantitative skin aging evaluation with a PA imaging system.
AB - Skin aging caused by ultraviolet light exposure is one of the serious problems from the viewpoint of beauty and healthcare. This is because ultraviolet light can cause age spot, wrinkles, at the worst case, skin cancer and so on. To evaluate skin aging, various modalities are being used, such as histopathological diagnosis, optical imaging (e.g. optical coherence tomography (OCT), second harmonic tomography (SHG)) and ultrasound examination (B-mode imaging). However, they have disadvantages in terms of invasiveness, penetration depth and tissue specificity, respectively. To overcome these defects, photoacoustic imaging (PAI), a novel modality was used in this work. This modality can portray differences of tissue characteristics non-invasively. In this work, human skin tissues in various degrees of photoaging (8 subjects, 2 kind of site each) were measured by using acoustic resolution photoacoustic microscopy (AR-PAM) to verify the feasibility of quantitative skin aging evaluation with PA technique. The effects of photoaging progress on the signal intensity were investigated. The results demonstrated that the PA signal from the dermis increases as photoaging progresses. These analyses demonstrate the feasibility of quantitative skin aging evaluation with a PA imaging system.
KW - dermis
KW - epidermis
KW - non-invasive
KW - optoacoustic
KW - skin section
KW - subcutaneous tissue
KW - t-test
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U2 - 10.1117/12.2579085
DO - 10.1117/12.2579085
M3 - Conference contribution
AN - SCOPUS:85109102625
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
A2 - Oraevsky, Alexander A.
A2 - Wang, Lihong V.
PB - SPIE
T2 - Photons Plus Ultrasound: Imaging and Sensing 2021
Y2 - 6 March 2021 through 11 March 2021
ER -