Basic investigation of three-dimensional ultrasound tissue viscoelasticity microscope

Tsuyoshi Shilna, Masashi Yoshida, Makoto Yamakawa, Naotaka Nitta

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The mechanical properties, or elasticity and viscosity, of tissues reflect the pathological change of tissues caused by lifestyle-related diseases such as cancer and cardiac disease. Therefore, tissue elasticity imaging has been investigated for several years and a practical system applicable to clinical diagnosis has recently been developed. To diagnose the stage of disease progression and differentiate malignant from benign tumors precisely using parameters that represent tissue elasticity and viscosity, it is required to elucidate the quantitative relationship between these parameters and disease. However, no database for such a relationship has been yet established. With the aim of constructing such a database, we undertook to develop a three-dimensional (3D) tissue viscoelasticity microscope, with which we can quantitatively measure the 3D distribution of parameters of tissue elasticity and viscosity. Results of experiments using a phantom model made of konnyaku and acrylamide confirmed that the system could reveal differences in the elasticity and viscosity of tissues.

Original languageEnglish
Pages (from-to)4851-4857
Number of pages7
JournalJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Issue number7 B
Publication statusPublished - 2007 Jul 26
Externally publishedYes


  • Elastic modulus
  • Tissue characterization
  • Ultrasound microscope
  • Viscoelasticity

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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