Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood

Nobutaka Ohgami; Osamu Yamanoshita; Nguyen Dinh Thang; Ichiro Yajima; Chihiro Nakano; Wu Wenting; Shoko Ohnuma; Masashi Kato

doi:10.1016/j.envpol.2015.07.041

Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood

Nobutaka Ohgami, Osamu Yamanoshita, Nguyen Dinh Thang, Ichiro Yajima, Chihiro Nakano, Wu Wenting, Shoko Ohnuma, Masashi Kato

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.

Original language	English
Pages (from-to)	456-460
Number of pages	5
Journal	Environmental Pollution
Volume	206
DOIs	https://doi.org/10.1016/j.envpol.2015.07.041
Publication status	Published - 2015 Aug 14
Externally published	Yes

Keywords

Arsenic
CCA-treated wood
Chromium
Copper
Debris
Great East Japan Earthquake

ASJC Scopus subject areas

Toxicology
Pollution
Health, Toxicology and Mutagenesis

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10.1016/j.envpol.2015.07.041

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@article{93b1dbc44d154e909b04264bba2d8148,

title = "Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood",

abstract = "We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.",

keywords = "Arsenic, CCA-treated wood, Chromium, Copper, Debris, Great East Japan Earthquake",

author = "Nobutaka Ohgami and Osamu Yamanoshita and Thang, {Nguyen Dinh} and Ichiro Yajima and Chihiro Nakano and Wu Wenting and Shoko Ohnuma and Masashi Kato",

note = "Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research (A) ( 15H01743 and 15H02588 ), (B) ( 24390157 and 24406002 ) and (C) (No. 25460178 , 25340052 ), Grant-in-Aid for Challenging Exploratory Research ( 26670525 ), Grant-in-Aid for Scientific Research on Innovative Areas ( 24108001 ), Grants-in-Aid for Young Scientists (B) ( 22770008 ) and COE Project for Private Universities ( Nutritional Health Science Research Center ; No. S12010072 ) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Mitsui & Co., Ltd. Environment Fund, Foundation from Center for Advanced Medical and Clinical Research Nagoya University Hospital, Toyoaki Scholarship Foundation, the Mitsubishi Foundation, AEON Environmental Foundation and the JKA and its promotion funds from KEIRIN RACE. ",

year = "2015",

month = aug,

day = "14",

doi = "10.1016/j.envpol.2015.07.041",

language = "English",

volume = "206",

pages = "456--460",

journal = "Environmental Pollution",

issn = "0269-7491",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood

AU - Ohgami, Nobutaka

AU - Yamanoshita, Osamu

AU - Thang, Nguyen Dinh

AU - Yajima, Ichiro

AU - Nakano, Chihiro

AU - Wenting, Wu

AU - Ohnuma, Shoko

AU - Kato, Masashi

N1 - Funding Information: This study was supported in part by Grants-in-Aid for Scientific Research (A) ( 15H01743 and 15H02588 ), (B) ( 24390157 and 24406002 ) and (C) (No. 25460178 , 25340052 ), Grant-in-Aid for Challenging Exploratory Research ( 26670525 ), Grant-in-Aid for Scientific Research on Innovative Areas ( 24108001 ), Grants-in-Aid for Young Scientists (B) ( 22770008 ) and COE Project for Private Universities ( Nutritional Health Science Research Center ; No. S12010072 ) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Mitsui & Co., Ltd. Environment Fund, Foundation from Center for Advanced Medical and Clinical Research Nagoya University Hospital, Toyoaki Scholarship Foundation, the Mitsubishi Foundation, AEON Environmental Foundation and the JKA and its promotion funds from KEIRIN RACE.

PY - 2015/8/14

Y1 - 2015/8/14

N2 - We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.

AB - We showed that 2.1% of 233 pieces of lumber debris after the Great East Japan Earthquake was chromated copper arsenate (CCA)-treated wood. Since hexavalent chromium (Cr), copper (Cu) and pentavalent arsenic (As) in the debris may be diffused in the air via incineration, we exposed human lung normal (BEAS-2B) and carcinoma (A549) cells to Cr, Cu and As at the molar ratio in a representative CCA-treated wood. Co-exposure to 0.10 μM Cr and 0.06 μM As, which solely had no effect on colony formation, synergistically promoted colony formation in BEAS-2B cells, but not A549 cells, with activation of the PI3K/AKT pathway. Sole exposure and co-exposure to Cu showed limited effects. Since previous reports showed Cr and As concentrations to which human lungs might be exposed, our results suggest the importance to avoid diffusion of Cr and As in the air via incineration of debris including CCA-treated wood after the disaster.

KW - Arsenic

KW - CCA-treated wood

KW - Chromium

KW - Copper

KW - Debris

KW - Great East Japan Earthquake

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DO - 10.1016/j.envpol.2015.07.041

M3 - Article

C2 - 26275730

AN - SCOPUS:84939131317

SN - 0269-7491

VL - 206

SP - 456

EP - 460

JO - Environmental Pollution

JF - Environmental Pollution

ER -

Carcinogenic risk of chromium, copper and arsenic in CCA-treated wood

Abstract

Keywords

ASJC Scopus subject areas

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