TY - JOUR
T1 - Changes in plasma alpha and gamma tocopherol levels before and after long-term local hyperthermia in cancer patients
AU - Fukui, Koji
AU - Ostapenko, Valentina V.
AU - Abe, Kouichi
AU - Nishide, Takahiro
AU - Miyano, Motoshige
AU - Mune, Masatoshi
AU - Yukawa, Susumu
AU - Nishide, Iwao
N1 - Funding Information:
This work was supported by the Vitamin E Information and Technology Section, Eisai Co., Ltd, Tokyo, Japan and Department of Third Internal Medicine, Wakayama Medical University, Wakayama, Japan. We thank Dr Tanaka Yoshimasa of the Shouseikai Nishide Hospital for helpful suggestions.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/8
Y1 - 2006/8
N2 - Local hyperthermia is one of the heat therapies for cancer patients. The effect of this therapy is recognized to affect the immune function. On the other hand, researchers have recently suggested that vitamin E has not only antioxidant but also other functions including the immune function. However, the association between local hyperthermia therapy and vitamin E level is not yet well understood. Comparing plasma alpha and gamma tocopherol levels before and after the therapy, the basal levels of both tocopherols in the cancer patients did not significantly differ from those in healthy subjects. However, the interindividual difference in the basal levels was very wide in the cancer patients. After long-term local hyperthermia (more than 70 days), the levels of both tocopherols were significantly higher than the basal levels. This result suggests that long-term local hyperthermia therapy influences plasma tocopherol level in cancer patients; thus, an increase in vitamin E level may play an important role in the therapy of cancer patients.
AB - Local hyperthermia is one of the heat therapies for cancer patients. The effect of this therapy is recognized to affect the immune function. On the other hand, researchers have recently suggested that vitamin E has not only antioxidant but also other functions including the immune function. However, the association between local hyperthermia therapy and vitamin E level is not yet well understood. Comparing plasma alpha and gamma tocopherol levels before and after the therapy, the basal levels of both tocopherols in the cancer patients did not significantly differ from those in healthy subjects. However, the interindividual difference in the basal levels was very wide in the cancer patients. After long-term local hyperthermia (more than 70 days), the levels of both tocopherols were significantly higher than the basal levels. This result suggests that long-term local hyperthermia therapy influences plasma tocopherol level in cancer patients; thus, an increase in vitamin E level may play an important role in the therapy of cancer patients.
KW - Cancer
KW - Local hyperthermia
KW - Vitamin E
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U2 - 10.1080/10715760600750396
DO - 10.1080/10715760600750396
M3 - Article
C2 - 17015268
AN - SCOPUS:33749245704
SN - 1071-5762
VL - 40
SP - 893
EP - 899
JO - Free Radical Research
JF - Free Radical Research
IS - 8
ER -