Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA

Ichiro Kumagai; Tsuyoshi Takahashi; Keita Hamasaki; Akihiko Ueno; Hisakazu Mihara

doi:10.1016/S0960-894X(00)00006-8

Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA

Ichiro Kumagai, Tsuyoshi Takahashi, Keita Hamasaki, Akihiko Ueno, Hisakazu Mihara

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Peptides containing peptide nucleic acid (PNA) have been designed and synthesized to construct molecules recognizing a bulge or a loop structure of RNA. Such peptides were here designed from the HIV Rev protein that can bind the stem-loop IIB of the Rev responsive element (RRE) RNA. Variations of PNA modulated the binding affinities of the peptides to RRE IIB RNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(00)00006-8
Publication status	Published - 2000 Feb 21
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00006-8

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AU - Hamasaki, Keita

AU - Ueno, Akihiko

AU - Mihara, Hisakazu

PY - 2000/2/21

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Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA

Abstract

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