Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara; Yoshihisa Hirota; Kimie Nakagawa; Maya Kamao; Naoko Tsugawa; Toshio Okano

doi:10.1016/j.bmc.2007.12.025

Design and synthesis of biologically active analogues of vitamin K₂: Evaluation of their biological activities with cultured human cell lines

Yoshitomo Suhara, Yoshihisa Hirota, Kimie Nakagawa, Maya Kamao, Naoko Tsugawa, Toshio Okano

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Novel ω-oxygenated vitamin K₂ analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K₂ analogues for the development of new drugs.

Original language	English
Pages (from-to)	3108-3117
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.bmc.2007.12.025
Publication status	Published - 2008 Mar 15
Externally published	Yes

Keywords

K acid
Menaquinone-4
Metabolite
Vitamin K
ω-Oxidation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2007.12.025

Cite this

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AU - Suhara, Yoshitomo

AU - Hirota, Yoshihisa

AU - Nakagawa, Kimie

AU - Kamao, Maya

AU - Tsugawa, Naoko

AU - Okano, Toshio

PY - 2008/3/15

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KW - Menaquinone-4

KW - Metabolite

KW - Vitamin K

KW - ω-Oxidation

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