The reactions of various alkyl halides with the metallo enamines generated from racemic and optically pure N-C axially chiral mebroqualone derivatives were found to proceed with a synthetically attractive stereochemical outcome (up to 99% yield and up to dr = 26:1) allowing preparation of a structurally new type of pharmaceutically interesting compounds possessing elements of axial and central chirality.
|Number of pages||4|
|Publication status||Published - 2017 May 19|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry