α-Iodination reaction of 4-alkenylamide with a β-chiral center proceeds with high diastereoseletivity to give syn α-iodoalkenamide through the formation of cyclic ketene N,O-acetal and subsequent α-iodination from the opposite side of a β-substituent.
|Number of pages||10|
|Publication status||Published - 1997 May 19|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry