TY - JOUR
T1 - Effects of alcohol on hemodynamic and cardiovascular reaction in different genotypes
AU - Obata, Akiko
AU - Morimoto, Kanehisa
AU - Sato, Hiroki
AU - Takeshita, Tatsuya
AU - Kawaguchi, Hideo
AU - Koizumi, Hideaki
AU - Maki, Atsushi
N1 - Funding Information:
This study was supported by Millennium Project Foundation of the Education, Culture, Sports, Science, and Technology Agency of the Japanese Government. We thank the study participants, and the administrative and teaching staff who generously offered willing cooperation.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2005/5/30
Y1 - 2005/5/30
N2 - This study assessed hemodynamic changes associated with alcohol intake in people who have different sensitivities to alcohol due to an inactive form of mitochondrial aldehyde dehydrogenase (ALDH). People with ALDH2*1/*2 are more sensitive to alcohol than people with ALDH2*1/*1. Six ALDH2*1/*1 subjects and four ALDH2*1/*2 subjects participated in this study. The subjects drank whisky with water (0.4 ml/kg of ethanol). Optical topography (Hitachi Medical Corporation: ETG-100) was used to measure hemodynamic changes in an occipital region during visual stimulation. Hemodynamic changes, heart rate, mean blood pressure, and reaction time were measured 20 min before, immediately after, and 20, 40, and 60 min after alcohol intake. Breath-alcohol concentration was measured at each of the assessment points. After alcohol intake, the hemodynamic peak value, peak time, reaction time, and heart rate of the ALDH2*1/*2 subjects differed from those of the ALDH2*1/*1 subjects. The hemodynamic peak value and reaction time gradually increased 60 min after alcohol exposure, and the peak time was shortest 20 min after alcohol intake. These results might reflect different acetaldehyde levels causing changes in the reactivity of the vascular smooth muscle and cerebral activity in the visual cortex.
AB - This study assessed hemodynamic changes associated with alcohol intake in people who have different sensitivities to alcohol due to an inactive form of mitochondrial aldehyde dehydrogenase (ALDH). People with ALDH2*1/*2 are more sensitive to alcohol than people with ALDH2*1/*1. Six ALDH2*1/*1 subjects and four ALDH2*1/*2 subjects participated in this study. The subjects drank whisky with water (0.4 ml/kg of ethanol). Optical topography (Hitachi Medical Corporation: ETG-100) was used to measure hemodynamic changes in an occipital region during visual stimulation. Hemodynamic changes, heart rate, mean blood pressure, and reaction time were measured 20 min before, immediately after, and 20, 40, and 60 min after alcohol intake. Breath-alcohol concentration was measured at each of the assessment points. After alcohol intake, the hemodynamic peak value, peak time, reaction time, and heart rate of the ALDH2*1/*2 subjects differed from those of the ALDH2*1/*1 subjects. The hemodynamic peak value and reaction time gradually increased 60 min after alcohol exposure, and the peak time was shortest 20 min after alcohol intake. These results might reflect different acetaldehyde levels causing changes in the reactivity of the vascular smooth muscle and cerebral activity in the visual cortex.
KW - Alcohol
KW - Aldehyde dehydrogenase
KW - Cardiovascular change
KW - Hemodynamic change
KW - Optical topography
KW - Visual stimulation
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U2 - 10.1016/j.pscychresns.2005.04.001
DO - 10.1016/j.pscychresns.2005.04.001
M3 - Article
C2 - 15936929
AN - SCOPUS:20444387559
SN - 0925-4927
VL - 139
SP - 65
EP - 72
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 1
ER -