Effects of high gravity on amphibian development.

Akihiko Kashiwagi, Hideki Hanada, Satomi Kawakami, Hideo Kubo, Tadashi Shinkai, Hirotada Fujii, Keiko Kashiwagi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


In order to clarify the possible effects of high gravity environments on eggs and developing embryos, Rana rugosa and Xenopus laevis fertilized eggs and early embryos were raised in 2 G, 5 G, 7 G and 10 G up to the hatched tadpole stage. The results showed that: (1) High gravity significantly retarded the development of eggs and embryos beginning treatment before the blastula stage and induced various abnormalities, including two heads and microcephally suggesting that high gravity is apt to disrupt the animal-vegital axis. On the other hand, embryos beginning treatment after the gastrula stage showed a striking increase in the number of normal-appearing feeding tadpoles. (2) Autopsy revealed that brains, notochords and muscles were reduced in development and differentiation for embryos and tadpoles developed in high gravity. (3) It seems likely that the system for hydrogen peroxide detoxification develops abnormally in high gravity-treated embryos and tadpoles, which probably results in oxidative stress, leading to considerable cell damage.

Original languageEnglish
Pages (from-to)215-216
Number of pages2
JournalBiological sciences in space = Uchū seibutsu kagaku
Issue number3
Publication statusPublished - 2003 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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