Evaluation of inflammatory degree using model rats by multi-wavelength photoacoustic imaging system

Kohei Ogawa, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Arthritis, which is associated with local articular rigidity, swelling and pain as well as systemic development of fever and a sense of fatigue, is a disorder leading quickly to deterioration of quality of life. Approximately 300,000 rheumatoid arthritis patients reside in Japan alone1: 1% of the world's population has the disorder worldwide. Although X-ray CT, MRI, and ultrasonic Doppler method are used for examination and diagnosis, various difficulties persist such as radiation exposure, administration of contrast agents, and difficulty in earlier diagnosis and quantitative evaluation. To resolve these difficulties, we developed a handheld photoacoustic imaging system. This study investigated the feasibility of evaluating the degree of inflammation using photoacoustic imaging with multiple wavelengths using in vivo measurements of model rats. Changes in signal intensity depending on the presence or absence of the disorder were examined. Results confirmed that the signal intensity can be intensified at diseased joints. Then, the changes with different time elapsed from drug administration were examined using rats. Results clarified that the degree of inflammation can be evaluated by photoacoustic spectral shapes, which change along with the progress of the inflammation. These analyses verified the usefulness of photoacoustic imaging for diagnosing and evaluating arthritis.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2020
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510632431
Publication statusPublished - 2020
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States
Duration: 2020 Feb 22020 Feb 5

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2020
Country/TerritoryUnited States
CitySan Francisco


  • Handheld photoacoustic imaging system
  • Inflammation
  • Optoacoustic imaging
  • Oxygen saturation
  • Rheumatoid

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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