Functional imaging of cat primary visual cortex with optical coherence tomography

Uma Maheswari Rajagopalan, Hideyuki Takaoka, Ryota Homma, Hirofumi Kadono, Manabu Tanifuji

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We report the application of Optical coherence tomography (OCT) for visualizing a one dimensional depth resolved functional structure of cat brain in vivo. The OCT system is based on the known fact that neural activation induces structural changes such as capillary dilation and cellular swelling. Detecting these changes as an amplitude change of the scattered light, an OCT signal reflecting neural activity i.e., fOCT (functional OCT) could be obtained. Experiments have been done to obtain a depth resolved stimulus-specific profile of activation in cat visual cortex. Our results in one dimension indicate that indeed an orientation dependent functional signal could be obtained. Further, we show that this depth resolved fOCT signal is well correlated with the stimulus dependent column determined by OISI. Based on the results, the smallest functional unit in depth, resolved by the proposed system is around 40 μm. We are extending our system to perform two dimensional functional imaging.

Original languageEnglish
Pages (from-to)128-136
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Issue number1
Publication statusPublished - 2002 Jun 14
Externally publishedYes


  • Absorption change
  • Brain
  • Depth resolved functional profile
  • Functional Optical coherence tomography
  • Optical coherence tomography
  • Optical intrinsic signal imaging
  • Primary visual cortex
  • Scattering change
  • Visualization of neural activity
  • Volumetric imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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