Glucose driven drug release system using improved decompression unit

Daisuke Mori, Koji Kurihara, Munkhjargal Munkhbayar, Koji Toma, Takahiro Arakawa, Kazuyoshi Yano, Kohji Mitsubayashi

Research output: Contribution to journalArticlepeer-review


In this work, an enhanced performance of an enzymatic chemo-mechanical actuator that can convert the chemical energy of glucose into mechanical energy for autonomous drug release without an electrical power is reported. The novel biochemical approach is based on increasing the decompression rate in a "vacuum unit" by fabricating enzyme co-immobilized membrane by multiple enzymes. Among the enzymes (glucose oxidase (GOD), pyranose oxidase (POD), alcohol oxidase (AOD)), which can oxidize glucose and/or glucono-1.5-lactone evaluated in co-immobilization designs within the vacuum unit, the highest decompression was obtained with POD+GOD, which was 3 times higher than that of the conventional organic engine with only GOD. Furthermore, the decompression rate of -7.4 Pa·cm3/sec in the vacuum unit necessary to drive the drug release system was obtained at 10 mmol/L glucose, which is close to the human blood sugar level. In conclusion, the vacuum unit is a promising device for development of a chemomechanical system driven by human blood sugar for the diabetes treatment.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalIEEJ Transactions on Sensors and Micromachines
Issue number6
Publication statusPublished - 2017
Externally publishedYes


  • Actuator
  • Blood sugar control
  • Chemo-mechanical energy conversion
  • Diabetes
  • Drug release
  • Enzyme

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering


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