Immunohistochemical study of localization of γ-glutamyl transpeptidase in the rat brain

M. Ogawa, M. Shiozawa, Y. Hiraoka, Y. Takeuchi, S. Aiso

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


γ-glutamyl transpeptidase (γ-GTP) is a membrane-bound enzyme which is known to play a crucial role in active transport of amino acids across membrane barriers. We prepared a monoclonal antibody recognizing specifically rat γ-GTP and investigated localization of the enzyme in the rat brain by immunohistochemistry with this antibody. The antigen was localized on the ependyma, epithelia of the choroid plexus and microvessels. More precise localization of γ-GTP was examined with immuno-electron microscopy. The antigen was recognized on the microvilli and cilia of the ependymal cells, microvilli of the choroid epithelial cells and luminal membranes of the vascular endothelial cells.

Original languageEnglish
Pages (from-to)597-601
Number of pages5
JournalTissue and Cell
Issue number6
Publication statusPublished - 1998
Externally publishedYes


  • Choroid plexus
  • Ependymal cell
  • Immunohistochemistry
  • Vascular endothelial cell
  • γ-glutamyl transpeptidase

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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