Mapping viscoelastic properties by multi-line (ML) acoustic radiation force

Mikako Gomyo, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In these days ultrasound studies of non-invasive diagnostic methods using the elastic property of tissue have showed very promising results. Biological soft tissues are viscoelastic in nature; therefore several recent studies have shown the feasibility of shear wave dispersion in order to express viscosity which is considered to be valid for early diagnoses. Shear wave Dispersion Ultrasound Vibrometry (SDUV) has been conducted under ex vivo and in vivo conditions, which could estimate the value of shear elasticity and viscosity from a 40 x 40 mm2 area. In this study, our proposed Multi-line (ML) acoustic radiation force method could map shear elasticity and viscosity at 0.2 x 0.2 mm2 pixel in 25.6 mm width and 29.6 mm depth area. ML uses seven focus points in depth to create much planar shear wave than ever, and twenty pushing line to obtain data such a broader area than ever. These sequences contribute to express precise values of shear elasticity and viscosity at each pixel. A 10% gelatin phantom with a 10% gelatin and 1% xanthan gum mixture inclusion was prepared for ML experiment, and one homogenous phantom made of the same concentrations as the background of ML experiments was for ML and SDUV experiments three times to validate. The ML measurement resulted μ41 = 1.129±0.118 kPa, μ42 = 0.893±0.090 Pas in the 10% gelatin background; their corresponding SDUV measurement were μ41 = 1.250±0.129 kPa, μ42 = 0.833±0.098 Pas in 10% gelatin phantom. Though further evaluations such as frequency and rheological model are required, the results could show the effectiveness of this proposed method in mapping viscoelasticity and the feasibility of in vivo and ex vivo experiments.

Original languageEnglish
Title of host publicationMedical Imaging 2015
Subtitle of host publicationUltrasonic Imaging and Tomography
EditorsNeb Duric, Johan G. Bosch
ISBN (Electronic)9781628415094
Publication statusPublished - 2015
Externally publishedYes
EventMedical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States
Duration: 2015 Feb 222015 Feb 23

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2015: Ultrasonic Imaging and Tomography
Country/TerritoryUnited States


  • Acoustic radiation force
  • SDUV
  • Shear wave
  • Viscoelasticity
  • Viscosity
  • Voigt

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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