Mechanosensitivity of ion channels based on protein-lipid interactions

Kenjiro Yoshimura, Masahiro Sokabe

Research output: Contribution to journalReview articlepeer-review

42 Citations (Scopus)


Ion channels forma group ofmembrane proteins that pass ions through a pore beyond the energy barrier of the lipid bilayer. The structure of the transmembrane segment of membrane proteins is influenced by the charges and the hydrophobicity of the surrounding lipids and the pressure on its surface. A mechanosensitive channel is specifically designed to change its conformation in response to changes in the membrane pressure (tension). However, mechanosensitive channels are not the only group that is sensitive to the physical environment of the membrane: voltage-gated channels are also amenable to the lipid environment. In this article, we review the structure and gating mechanisms of the mechanosensitive channels and voltage-gated channels and discuss how their functions are affected by the physical properties of the lipid bilayer.

Original languageEnglish
Pages (from-to)S307-S320
JournalJournal of the Royal Society Interface
Issue numberSUPPL. 3
Publication statusPublished - 2010 Jun 6
Externally publishedYes


  • Ion channels
  • Mechanosensitive channel of large conductance
  • Mechanosensitive channel of small conductance
  • Mechanosensitive channels
  • Membrane lipid

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering


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