Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave

Atsushi Takano; Tasuku Kon; Yasubumi Furuya; Katsumi Mochitate; Masato Tanaka; Nobuyuki Futai

doi:10.1109/MHS.2013.6710472

Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave

Atsushi Takano, Tasuku Kon, Yasubumi Furuya, Katsumi Mochitate, Masato Tanaka, Nobuyuki Futai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).

Original language	English
Title of host publication	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Publisher	IEEE Computer Society
ISBN (Print)	9781479915293
DOIs	https://doi.org/10.1109/MHS.2013.6710472
Publication status	Published - 2013
Event	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan Duration: 2013 Nov 10 → 2013 Nov 13

Publication series

Name	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013

Conference

Conference	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Country/Territory	Japan
City	Nagoya
Period	13/11/10 → 13/11/13

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/MHS.2013.6710472

Cite this

Takano, A., Kon, T., Furuya, Y., Mochitate, K., Tanaka, M., & Futai, N. (2013). Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 Article 6710472 (2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013). IEEE Computer Society. https://doi.org/10.1109/MHS.2013.6710472

Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave. / Takano, Atsushi; Kon, Tasuku; Furuya, Yasubumi et al.
2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society, 2013. 6710472 (2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Takano, A, Kon, T, Furuya, Y, Mochitate, K, Tanaka, M & Futai, N 2013, Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave. in 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013., 6710472, 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013, IEEE Computer Society, 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013, Nagoya, Japan, 13/11/10. https://doi.org/10.1109/MHS.2013.6710472

Takano A, Kon T, Furuya Y, Mochitate K, Tanaka M, Futai N. Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society. 2013. 6710472. (2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013). doi: 10.1109/MHS.2013.6710472

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abstract = "We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).",

author = "Atsushi Takano and Tasuku Kon and Yasubumi Furuya and Katsumi Mochitate and Masato Tanaka and Nobuyuki Futai",

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AU - Takano, Atsushi

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AU - Furuya, Yasubumi

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AU - Tanaka, Masato

AU - Futai, Nobuyuki

PY - 2013

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AB - We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).

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Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave

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