Non-invasive brain-function imaging by optical topography

Hideaki Koizumi, Atsushi Maki, Tsuyoshi Yamamoto, Hiroki Sato, Yukari Yamamoto, Hideo Kawaguchi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Cerebral cortex refers to the near-surface regions of the brain. While these regions are known to support the complex brain functions of man, the functions are still not well understood. However, non-invasive techniques for forming images of changing regional blood flow (rCBF) or blood volume (rCBV) in the cerebral cortex have recently become available. One of the techniques, called optical topography, shows promise not only for medical treatment but also for learning- and education-related studies. The principle is to irradiate the head with near-infrared light and analyze reflection and scattering at the brain's surface.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalTrAC - Trends in Analytical Chemistry
Issue number2
Publication statusPublished - 2005 Feb
Externally publishedYes


  • Brain function
  • Brain imaging
  • Near infrared spectroscopy
  • Non invasive analysis
  • Optical topography

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy


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