On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure

Tomohiro Kawahara; Masakuni Sugita; Masaya Hagiwara; Yoko Yamanishi; Fumihito Arai; Hiroyuki Kawano; Ikuko Shihira-Ishikawa; Atsushi Miyawaki

doi:10.1109/ICRA.2012.6224966

On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure

Tomohiro Kawahara, Masakuni Sugita, Masaya Hagiwara, Yoko Yamanishi, Fumihito Arai, Hiroyuki Kawano, Ikuko Shihira-Ishikawa, Atsushi Miyawaki

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

In this paper, we introduce an untethered type of magnetically driven microtool (MMT) with a force sensing function to investigate the stimulus characteristics of aquatic microorganisms in a microfluidic chip. The microchip is composed of the proposed MMTs, which have a Si-Ni hybrid structure, a transparent cover made of polydimethylsiloxane (PDMS), a glass substrate, and a microspacer to prevent both friction during the force measurement and damage to the micropattern of the MMT. The fabrication and drive performance of the MMT, which is actuated by permanent magnets from the outside of the microchip, verified in basic experiments. Finally, we succeeded in on-chip manipulation and sensing of microorganisms using this MMT, which we found to be easy to use.

Original language	English
Title of host publication	2012 IEEE International Conference on Robotics and Automation, ICRA 2012
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4112-4117
Number of pages	6
ISBN (Print)	9781467314039
DOIs	https://doi.org/10.1109/ICRA.2012.6224966
Publication status	Published - 2012 Jan 1
Event	2012 IEEE International Conference on Robotics and Automation, ICRA 2012 - Saint Paul, MN, United States Duration: 2012 May 14 → 2012 May 18

Publication series

Name	Proceedings - IEEE International Conference on Robotics and Automation
ISSN (Print)	1050-4729

Conference

Conference	2012 IEEE International Conference on Robotics and Automation, ICRA 2012
Country/Territory	United States
City	Saint Paul, MN
Period	12/5/14 → 12/5/18

ASJC Scopus subject areas

Software
Control and Systems Engineering
Artificial Intelligence
Electrical and Electronic Engineering

Access to Document

10.1109/ICRA.2012.6224966

Cite this

Kawahara, T., Sugita, M., Hagiwara, M., Yamanishi, Y., Arai, F., Kawano, H., Shihira-Ishikawa, I., & Miyawaki, A. (2012). On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure. In 2012 IEEE International Conference on Robotics and Automation, ICRA 2012 (pp. 4112-4117). [6224966] (Proceedings - IEEE International Conference on Robotics and Automation). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICRA.2012.6224966

On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure. / Kawahara, Tomohiro; Sugita, Masakuni; Hagiwara, Masaya et al.
2012 IEEE International Conference on Robotics and Automation, ICRA 2012. Institute of Electrical and Electronics Engineers Inc., 2012. p. 4112-4117 6224966 (Proceedings - IEEE International Conference on Robotics and Automation).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kawahara, T, Sugita, M, Hagiwara, M, Yamanishi, Y, Arai, F, Kawano, H, Shihira-Ishikawa, I & Miyawaki, A 2012, On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure. in 2012 IEEE International Conference on Robotics and Automation, ICRA 2012., 6224966, Proceedings - IEEE International Conference on Robotics and Automation, Institute of Electrical and Electronics Engineers Inc., pp. 4112-4117, 2012 IEEE International Conference on Robotics and Automation, ICRA 2012, Saint Paul, MN, United States, 12/5/14. https://doi.org/10.1109/ICRA.2012.6224966

Kawahara T, Sugita M, Hagiwara M, Yamanishi Y, Arai F, Kawano H et al. On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure. In 2012 IEEE International Conference on Robotics and Automation, ICRA 2012. Institute of Electrical and Electronics Engineers Inc. 2012. p. 4112-4117. 6224966. (Proceedings - IEEE International Conference on Robotics and Automation). doi: 10.1109/ICRA.2012.6224966

Kawahara, Tomohiro ; Sugita, Masakuni ; Hagiwara, Masaya et al. / On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure. 2012 IEEE International Conference on Robotics and Automation, ICRA 2012. Institute of Electrical and Electronics Engineers Inc., 2012. pp. 4112-4117 (Proceedings - IEEE International Conference on Robotics and Automation).

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title = "On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure",

abstract = "In this paper, we introduce an untethered type of magnetically driven microtool (MMT) with a force sensing function to investigate the stimulus characteristics of aquatic microorganisms in a microfluidic chip. The microchip is composed of the proposed MMTs, which have a Si-Ni hybrid structure, a transparent cover made of polydimethylsiloxane (PDMS), a glass substrate, and a microspacer to prevent both friction during the force measurement and damage to the micropattern of the MMT. The fabrication and drive performance of the MMT, which is actuated by permanent magnets from the outside of the microchip, verified in basic experiments. Finally, we succeeded in on-chip manipulation and sensing of microorganisms using this MMT, which we found to be easy to use.",

author = "Tomohiro Kawahara and Masakuni Sugita and Masaya Hagiwara and Yoko Yamanishi and Fumihito Arai and Hiroyuki Kawano and Ikuko Shihira-Ishikawa and Atsushi Miyawaki",

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AU - Kawahara, Tomohiro

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AU - Hagiwara, Masaya

AU - Yamanishi, Yoko

AU - Arai, Fumihito

AU - Kawano, Hiroyuki

AU - Shihira-Ishikawa, Ikuko

AU - Miyawaki, Atsushi

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AB - In this paper, we introduce an untethered type of magnetically driven microtool (MMT) with a force sensing function to investigate the stimulus characteristics of aquatic microorganisms in a microfluidic chip. The microchip is composed of the proposed MMTs, which have a Si-Ni hybrid structure, a transparent cover made of polydimethylsiloxane (PDMS), a glass substrate, and a microspacer to prevent both friction during the force measurement and damage to the micropattern of the MMT. The fabrication and drive performance of the MMT, which is actuated by permanent magnets from the outside of the microchip, verified in basic experiments. Finally, we succeeded in on-chip manipulation and sensing of microorganisms using this MMT, which we found to be easy to use.

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On-chip manipulation and sensing of microorganisms by magnetically driven microtools with a force sensing structure

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