PH-responsive nanoemulsions for controlled drug release

Feng Liu; Shudong Lin; Zuoquan Zhang; Jiwen Hu; Guojun Liu; Yuanyuan Tu; Yang Yang; Hailiang Zou; Yangmiao Mo; Lei Miao

doi:10.1021/bm4018484

PH-responsive nanoemulsions for controlled drug release

Feng Liu, Shudong Lin, Zuoquan Zhang, Jiwen Hu, Guojun Liu, Yuanyuan Tu, Yang Yang, Hailiang Zou, Yangmiao Mo, Lei Miao

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Three ternary graft copolymers bearing polystyrene (PS), poly(ethylene glycol) methyl ether (MPEG), and poly(acrylic acid) (PAA) side chains were synthesized and characterized. At pH = 7.4, these copolymers stabilized doxorubicin (DOX)-containing benzyl benzoate (BBZ) nanoemulsion droplets in water and formed a compact polymer layer to inhibit DOX release. Upon lowering the solution pH to 5.0, the AA groups dissociated less and became less soluble. Moreover, the neutralized AA groups formed presumably H-bonded complexes with the EG units, reducing the solubility of the EG units. This dual action drastically shifted the hydrophilic and hydrophobic balance of the copolymer and caused the original stabilizing polymer layer to rupture and the nanoemulsion droplets to aggregate, releasing DOX. The rate and extent of DOX release could be increased by matching the numbers of PAA and MPEG chains per graft copolymer. In addition, these nanoemulsions were not toxic and entered human carcinoma cells, releasing DOX there. Thus, these nanoemulsions have potential as drug delivery vehicles.

Original language	English
Pages (from-to)	968-977
Number of pages	10
Journal	Biomacromolecules
Volume	15
Issue number	3
DOIs	https://doi.org/10.1021/bm4018484
Publication status	Published - 2014 Mar 10
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

10.1021/bm4018484

Cite this

@article{ba9f35cad39945e29849f7ce22ba3fe1,

title = "PH-responsive nanoemulsions for controlled drug release",

abstract = "Three ternary graft copolymers bearing polystyrene (PS), poly(ethylene glycol) methyl ether (MPEG), and poly(acrylic acid) (PAA) side chains were synthesized and characterized. At pH = 7.4, these copolymers stabilized doxorubicin (DOX)-containing benzyl benzoate (BBZ) nanoemulsion droplets in water and formed a compact polymer layer to inhibit DOX release. Upon lowering the solution pH to 5.0, the AA groups dissociated less and became less soluble. Moreover, the neutralized AA groups formed presumably H-bonded complexes with the EG units, reducing the solubility of the EG units. This dual action drastically shifted the hydrophilic and hydrophobic balance of the copolymer and caused the original stabilizing polymer layer to rupture and the nanoemulsion droplets to aggregate, releasing DOX. The rate and extent of DOX release could be increased by matching the numbers of PAA and MPEG chains per graft copolymer. In addition, these nanoemulsions were not toxic and entered human carcinoma cells, releasing DOX there. Thus, these nanoemulsions have potential as drug delivery vehicles.",

author = "Feng Liu and Shudong Lin and Zuoquan Zhang and Jiwen Hu and Guojun Liu and Yuanyuan Tu and Yang Yang and Hailiang Zou and Yangmiao Mo and Lei Miao",

year = "2014",

month = mar,

day = "10",

doi = "10.1021/bm4018484",

language = "English",

volume = "15",

pages = "968--977",

journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - PH-responsive nanoemulsions for controlled drug release

AU - Liu, Feng

AU - Lin, Shudong

AU - Zhang, Zuoquan

AU - Hu, Jiwen

AU - Liu, Guojun

AU - Tu, Yuanyuan

AU - Yang, Yang

AU - Zou, Hailiang

AU - Mo, Yangmiao

AU - Miao, Lei

PY - 2014/3/10

Y1 - 2014/3/10

N2 - Three ternary graft copolymers bearing polystyrene (PS), poly(ethylene glycol) methyl ether (MPEG), and poly(acrylic acid) (PAA) side chains were synthesized and characterized. At pH = 7.4, these copolymers stabilized doxorubicin (DOX)-containing benzyl benzoate (BBZ) nanoemulsion droplets in water and formed a compact polymer layer to inhibit DOX release. Upon lowering the solution pH to 5.0, the AA groups dissociated less and became less soluble. Moreover, the neutralized AA groups formed presumably H-bonded complexes with the EG units, reducing the solubility of the EG units. This dual action drastically shifted the hydrophilic and hydrophobic balance of the copolymer and caused the original stabilizing polymer layer to rupture and the nanoemulsion droplets to aggregate, releasing DOX. The rate and extent of DOX release could be increased by matching the numbers of PAA and MPEG chains per graft copolymer. In addition, these nanoemulsions were not toxic and entered human carcinoma cells, releasing DOX there. Thus, these nanoemulsions have potential as drug delivery vehicles.

AB - Three ternary graft copolymers bearing polystyrene (PS), poly(ethylene glycol) methyl ether (MPEG), and poly(acrylic acid) (PAA) side chains were synthesized and characterized. At pH = 7.4, these copolymers stabilized doxorubicin (DOX)-containing benzyl benzoate (BBZ) nanoemulsion droplets in water and formed a compact polymer layer to inhibit DOX release. Upon lowering the solution pH to 5.0, the AA groups dissociated less and became less soluble. Moreover, the neutralized AA groups formed presumably H-bonded complexes with the EG units, reducing the solubility of the EG units. This dual action drastically shifted the hydrophilic and hydrophobic balance of the copolymer and caused the original stabilizing polymer layer to rupture and the nanoemulsion droplets to aggregate, releasing DOX. The rate and extent of DOX release could be increased by matching the numbers of PAA and MPEG chains per graft copolymer. In addition, these nanoemulsions were not toxic and entered human carcinoma cells, releasing DOX there. Thus, these nanoemulsions have potential as drug delivery vehicles.

UR - http://www.scopus.com/inward/record.url?scp=84896772475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896772475&partnerID=8YFLogxK

U2 - 10.1021/bm4018484

DO - 10.1021/bm4018484

M3 - Article

C2 - 24527876

AN - SCOPUS:84896772475

SN - 1525-7797

VL - 15

SP - 968

EP - 977

JO - Biomacromolecules

JF - Biomacromolecules

IS - 3

ER -

PH-responsive nanoemulsions for controlled drug release

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this