TY - JOUR
T1 - Remarkable stabilization of the α-helix structure by an intramolecular host-guest bridge in a cyclodextrin-peptide hybrid
AU - Hamasaki, Keita
AU - Suzuki, Ryosuke
AU - Mihara, Hisakazu
AU - Ueno, Akihiko
PY - 2001/2/28
Y1 - 2001/2/28
N2 - A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of γ-cyclodextrin, cholic acid, and a dansyl fluorophore in the side chain has been prepared. In this novel CD-peptide, the cholic acid unit acts as an internal guest and forms an intramolecular inclusion complex with γ-cyclodextrin in the CD-peptide. This intramolecular complex works as a host-guest bridge in the CD-peptide and remarkably stabilizes the α-helix structure of the CD-peptide.
AB - A cyclodextrin-peptide hybrid (CD-peptide) bearing three units of γ-cyclodextrin, cholic acid, and a dansyl fluorophore in the side chain has been prepared. In this novel CD-peptide, the cholic acid unit acts as an internal guest and forms an intramolecular inclusion complex with γ-cyclodextrin in the CD-peptide. This intramolecular complex works as a host-guest bridge in the CD-peptide and remarkably stabilizes the α-helix structure of the CD-peptide.
UR - http://www.scopus.com/inward/record.url?scp=0035530399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035530399&partnerID=8YFLogxK
U2 - 10.1002/1521-3927(20010201)22:4<262::AID-MARC262>3.0.CO;2-O
DO - 10.1002/1521-3927(20010201)22:4<262::AID-MARC262>3.0.CO;2-O
M3 - Article
AN - SCOPUS:0035530399
SN - 1022-1336
VL - 22
SP - 262
EP - 265
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 4
ER -