Special Articles on Coordination Chemistry of Biologically Important SubstancesNote Complex Formation of a Model Compound of Anthracycline Antibiotics to Fe(lll) Ion and Its Dissociation along with Reduction

Masahiko Tachibana, Masamoto Iwaizumi

Research output: Contribution to journalArticlepeer-review

Abstract

1, 8-Dihydroxyanthraquinone (1, 8-DHAQ), one of model compounds for the anthraquinone moiety of some anthracycline antibiotics, forms coordination compounds with iron(Ill) ion in various metal/ligand ratios of 1/1 to 1/3. The EPR spectra show that 1, 8-DHAQ dissociates to give a metal-free semiquinone radical upon electrochemical reduction, though weak interaction with the metal ion still remains. The result suggests possible switching of coordination-dissociation between anthracyclines and metal ions which may be triggered by oxidation-reduction in the processes of redox cycles involved in anthracycline-dependent lipid peroxidation in biological systems where the presence of metal ions is considered to be essential.

Original languageEnglish
Pages (from-to)701-703
Number of pages3
JournalNippon Kagaku Kaishi
Volume1988
Issue number4
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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