Study for evaluation of skin aging with photoacoustic microscopy

Hiroki Hattori, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


Skin aging caused by ultraviolet light exposure is one of the serious problems from the viewpoint of beauty and healthcare. This is because ultraviolet light can cause age spot, wrinkles, at the worst case, skin cancer and so on. To evaluate skin aging, various modalities are being used, such as histopathological diagnosis, optical coherence tomography, ultrasound examination (B-mode imaging). However, they have disadvantages in terms of invasiveness, penetration depth and tissue specificity, respectively. To overcome these defects, photoacoustic imaging (PAI), a novel modality was used in this work. This modality can portray differences of tissue characteristics non-invasively. In this experiment, human skin tissues in various generations (i.e. various degrees of photo-aging) were measured by using optical resolution photoacoustic microscopy (OR-PAM) and acoustic resolution photoacoustic microscopy (AR-PAM). To verify the feasibility of quantitative skin aging evaluation with PA technique, signals from sectioned human skin (cheek and buttock; female from 28 to 95 years old) were measured with PA microscopy. The effects of photo-aging progress on the signal intensity were investigated. The results demonstrated that the PA signal from the dermis increases with aging progress. These analyses demonstrate the feasibility of quantitative skin aging evaluation with a PA imaging system.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2020
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510632431
Publication statusPublished - 2020
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States
Duration: 2020 Feb 22020 Feb 5

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2020
Country/TerritoryUnited States
CitySan Francisco


  • Dermis
  • Epidermis
  • Non-invasive
  • Optoacoustic
  • Skin section
  • Subcutaneous tissue

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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