Surface plasmon resonance imaging of Au nano-partifcle modified DNA monolayers

Akira Yamaguchi, Masayuki Hayashida, Saulius Juodkazis, Yoichiro Hara, Shigeki Matsuo, Hiroaki Misawa

Research output: Contribution to journalConference articlepeer-review


A probe DNA monolayer modified with Au nano-particles was prepared on an Au thin film and used for DNA hybridization detection by surface plasmon resonance (SPR) spectroscopy. This Au particle modified probe DNA monolayer resulted in about a 3.5 times larger SPR angle shift according to the hybridization reaction, compared to that found in a non-modified probe DNA monolayer. By comparison of the SPR image of the particle modified and non-modified probe DNA monolayer, this modification method was shown to be useful in improving the SPR signal for the detection of the unlabelled DNA molecules.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2002
Externally publishedYes
EventBiomedical Nanotechnology Architectures and Applications - San Jose, CA, United States
Duration: 2002 Jan 202002 Jan 24


  • AFM
  • Au nano-particle
  • DNA
  • Hybridization
  • SPR

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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