Surgery assistance system for continuous resection of brain tumors-proposal of continuous tumor resection forceps, tumor cell separation, dehydration, and isolation mechanism

Taro Koguchi, Funika Shimizu, Tomohiro Nagame, Yuka Goto, Hikaru Iwasaki, Akihiko Hanafusa, Motoki Takagi, Shahrol Mohamaddan, Kenichi Nomura, Yoshihiro Muragaki, Hiroshi Iseki, Ken Masamune, Toyohisa Akitaya

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The tumor resection ratio must be improved due the increased possibility of recurrence or malignancy. The purpose of this study was to develop a system that includes forceps with a continuous suction function and flow cytometry to diagnose the malignancy of the tumor for safe, accurate, and effective surgery. A newly developed continuous tumor resection forceps consists of a triple pipe structure, which enables continuous suction of the tumor by integrating the reflux water and suction system. The forceps includes tip opening/closure detection switch to control the adsorption and suction strength when tip is opened and closed. To perform accurate tumor diagnosis using flow cytometry, a filtering mechanism was developed for dehydrating reflux water from continuous suction forceps. In addition, a cell isolation mechanism comprising a roller pump and shear force loading mechanism was also newly developed. By using a triple pipe structure, a significantly larger tumor collection ratio was observed compared to the previous double-pipe structure. By performing suction pressure control with the opening/closure detection switch, inaccurate suction can be prevented. By widening the filter area of dehydration mechanism, it was possible to improve the reflux water dehydration ratio. The most appropriate filter area was 85 mm2. By using a newly developed cell isolation mechanism, the processing time can be reduced to less than 1/10 of the original time, keeping the same cell isolation ratio, when compared to the existing pipetting method. Neurosurgery assistance system with continuous tumor resection forceps and a cell separation, dehydration and isolation mechanism was developed. An effective and safe tumor resection, accurate and fast diagnosis of malignancy can be achieved by using the current system.

Original languageEnglish
Pages (from-to)877-885
Number of pages9
JournalInternational Journal of Computer Assisted Radiology and Surgery
Volume18
Issue number5
DOIs
Publication statusPublished - 2023 May

Keywords

  • Brain tumor
  • Cell isolation mechanism
  • Continuous tumor resection forceps
  • Flow cytometer
  • Reflux water

ASJC Scopus subject areas

  • Surgery
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Computer Science Applications
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

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