TY - JOUR
T1 - Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells
AU - Kimura, Kimito
AU - Hirota, Yoshihisa
AU - Kuwahara, Shigefumi
AU - Takeuchi, Atsuko
AU - Tode, Chisato
AU - Wada, Akimori
AU - Osakabe, Naomi
AU - Suhara, Yoshitomo
N1 - Funding Information:
Y.S. acknowledges The Naito Foundation. This study was supported in part by a Grant-in-Aid for Scientific Research KAKENHI (Grant 16K08325 to Y.S.) from the Japan Society for Promotion of Science.
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/3/23
Y1 - 2017/3/23
N2 - We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.
AB - We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.
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U2 - 10.1021/acs.jmedchem.6b01717
DO - 10.1021/acs.jmedchem.6b01717
M3 - Article
C2 - 28225275
AN - SCOPUS:85016267936
SN - 0022-2623
VL - 60
SP - 2591
EP - 2596
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 6
ER -