We synthesized new vitamin K2 analogues with ω-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.
|Number of pages||5|
|Journal||Journal of Medicinal Chemistry|
|Publication status||Published - 2015 Sept 10|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery