Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels

Zhao Xia Li; Man Geng Lu; Kun Wu; Yun Fei Zhang; Lei Miao; Yin Wen Li; Hui Long Guo; Jian Zheng

doi:10.1002/pen.23877

Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels

Zhao Xia Li, Man Geng Lu, Kun Wu, Yun Fei Zhang, Lei Miao, Yin Wen Li, Hui Long Guo, Jian Zheng

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (e-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(e-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery.

Original language	English
Pages (from-to)	223-230
Number of pages	8
Journal	Polymer Engineering and Science
Volume	55
Issue number	1
DOIs	https://doi.org/10.1002/pen.23877
Publication status	Published - 2015 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)
Polymers and Plastics
Materials Chemistry

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title = "Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels",

abstract = "A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (e-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(e-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery.",

author = "Li, {Zhao Xia} and Lu, {Man Geng} and Kun Wu and Zhang, {Yun Fei} and Lei Miao and Li, {Yin Wen} and Guo, {Hui Long} and Jian Zheng",

note = "Publisher Copyright: {\textcopyright} 2014 Society of Plastics Engineers.",

year = "2015",

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doi = "10.1002/pen.23877",

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T1 - Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels

AU - Li, Zhao Xia

AU - Lu, Man Geng

AU - Wu, Kun

AU - Zhang, Yun Fei

AU - Miao, Lei

AU - Li, Yin Wen

AU - Guo, Hui Long

AU - Zheng, Jian

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (e-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(e-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery.

AB - A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (e-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(e-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery.

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JO - Polymer Engineering and Science

JF - Polymer Engineering and Science

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ER -

Temperature-responsiveness and sustained delivery properties of macroporous PEG-co-PNIPAAm-co-PCL hydrogels

Abstract

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