Thermal properties and microstructures of methylated polyrotaxane solutions

Toshiyuki Kataoka, Masatoshi Kidowaki, Changming Zhao, Jun Araki, Takayuki Ikehara, Kohzo Ito

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aqueous solutions of polyrotaxanes consisting of poly(ethylene glycol) and methylated alpha-cyclodextrins (alpha-CD) were studied by means of differential scanning calorimetry (DSC), dynamic light scattering, and X-ray diffraction in order to investigate the effect of the degree of methylation on thermoresponsive behavior. Polyrotaxanes with a degree of methylation higher than 50% had a lower critical solution temperature (LCST) and showed reversible associations and dissociations in water. In the transmittance measurements, the cloud point of methylated polyrotaxanes (MePR) shifted to a lower temperature with an increase in the degree of methylation. The heating curve obtained by DSC for the nearly permethylated polyrotaxane showed one broad endothermic peak that was associated with the microcrystallization of methylated CDs by hydrophobic interactions. On the other hand, the DSC profiles for partially methylated polyrotaxanes had several endothermic peaks, indicating multiple phase transitions of the MePR solutions. The results imply that the thermal properties of the MePR-water system are significantly affected by not only the methyl groups on alpha-CDs but also by the remaining hydroxyl groups.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalCurrent Drug Discovery Technologies
Issue number4
Publication statusPublished - 2007 Dec 1
Externally publishedYes


  • Cyclodextrin
  • Differential scanning calorimetry
  • Polyrotaxane
  • Supramolecule
  • Thermoreversible gel

ASJC Scopus subject areas

  • Drug Discovery


Dive into the research topics of 'Thermal properties and microstructures of methylated polyrotaxane solutions'. Together they form a unique fingerprint.

Cite this