Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium

Masahiro Yamada, Tsuyoshi Kimura, Naoko Nakamura, Jun Watanabe, Nadia Kartikasari, Xindie He, Watcharaphol Tiskratok, Hayato Yoshioka, Hidenori Shinno, Hiroshi Egusa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The periodontium supports the teeth by dentoalveolar fibrous joints that serve unique oral functions. Endogenous regeneration of the periodontium around artificial teeth (dental implants) provides a cost-effective solution for the extension of healthy life expectancy but remains a challenge in regenerative medicine. Biomimetics can create smart biomaterials that tune endogenous cells at a tissue-material interface. Here, we created a smart titanium nanosurface mimicking the surface nanotopography and micromechanical properties of the tooth root cementum (TRC), which is essential for the induction of dentoalveolar fibrous joints to regenerate the periodontium. After transplantation into the rat renal capsule, only the titanium artificial tooth with the TRC-mimetic nanosurface formed a complex dentoalveolar fibrous joint structure, with bone tissue, periodontal ligament (PDL), and TRC, in the decellularized jawbone matrix. TRC-mimetic titanium implants induce the formation of functional periodontium, even in a jawbone implantation model, which generally causes osseointegration (ankyloses). In human PDL cells, TRC analogousness in the surface mechanical microenvironment regulates matrix mineralization through bone sialoprotein expression and phosphorus metabolism, which are critical for cementogenesis. Therefore, the titanium nanosurfaces with nanotopographical and mechanical microenvironments mimicking the TRC surface induce dentoalveolar fibrous joints for periodontal regeneration by interfacial tuning of endogenous cells.

Original languageEnglish
Pages (from-to)27703-27719
Number of pages17
JournalACS Applied Materials and Interfaces
Volume14
Issue number24
DOIs
Publication statusPublished - 2022 Jun 22

Keywords

  • biomimetics
  • dental implants
  • in situ tissue regeneration
  • nanotechnology
  • periodontium

ASJC Scopus subject areas

  • General Materials Science

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