Ultrasonic speed microscopy for imaging of coronary artery

Yoshifumi Saijo; Naohiro Hozumi; Cheolkyou Lee; Masayuki Nagao; Kazuto Kobayashi; Nagaya Oakada; Naohiko Tanaka; Esmeraldo dos Santos Filho; Hidehiko Sasaki; Motonao Tanaka; Tomoyuki Yambe

doi:10.1016/j.ultras.2006.06.050

Ultrasonic speed microscopy for imaging of coronary artery

Yoshifumi Saijo, Naohiro Hozumi, Cheolkyou Lee, Masayuki Nagao, Kazuto Kobayashi, Nagaya Oakada, Naohiko Tanaka, Esmeraldo dos Santos Filho, Hidehiko Sasaki, Motonao Tanaka, Tomoyuki Yambe

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic speed and attenuation of soft tissues. In the present study, we will propose a new concept ultrasonic speed microscopy that can measure the thickness and ultrasonic speed using fast Fourier transform of a single pulsed wave instead of continuous waves used in conventional SAM systems. Six coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 121 s and two-dimensional distribution of ultrasonic speed was obtained. The ultrasonic speed was 1720 m/s in the thickened intima with collagen fiber, 1520 m/s in lipid deposition underlying fibrous cap and 1830 m/s in calcified lesion in the intima. These basic measurements will help understanding echogenecity in intravascular ultrasound (IVUS) images. Imaging of coronary artery with the ultrasonic speed microscopy provides important information for study of IVUS coronary imaging.

Original language	English
Pages (from-to)	e51-e55
Journal	Ultrasonics
Volume	44
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/j.ultras.2006.06.050
Publication status	Published - 2006 Dec 22

Keywords

Acoustic microscopy
Atherosclerosis
Coronary artery
Ultrasonic speed

ASJC Scopus subject areas

Acoustics and Ultrasonics

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10.1016/j.ultras.2006.06.050

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title = "Ultrasonic speed microscopy for imaging of coronary artery",

abstract = "We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic speed and attenuation of soft tissues. In the present study, we will propose a new concept ultrasonic speed microscopy that can measure the thickness and ultrasonic speed using fast Fourier transform of a single pulsed wave instead of continuous waves used in conventional SAM systems. Six coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 121 s and two-dimensional distribution of ultrasonic speed was obtained. The ultrasonic speed was 1720 m/s in the thickened intima with collagen fiber, 1520 m/s in lipid deposition underlying fibrous cap and 1830 m/s in calcified lesion in the intima. These basic measurements will help understanding echogenecity in intravascular ultrasound (IVUS) images. Imaging of coronary artery with the ultrasonic speed microscopy provides important information for study of IVUS coronary imaging.",

keywords = "Acoustic microscopy, Atherosclerosis, Coronary artery, Ultrasonic speed",

author = "Yoshifumi Saijo and Naohiro Hozumi and Cheolkyou Lee and Masayuki Nagao and Kazuto Kobayashi and Nagaya Oakada and Naohiko Tanaka and {Santos Filho}, {Esmeraldo dos} and Hidehiko Sasaki and Motonao Tanaka and Tomoyuki Yambe",

note = "Funding Information: This study was supported by Grants-in-Aid for Scientific Research (Scientific Research (B) 15300178, Scientific Research (B) 15360217) from the Japan Society for the Promotion of Science and Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare for the Research on Advanced Medical Technology (H17-Nano-001).",

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AU - Saijo, Yoshifumi

AU - Hozumi, Naohiro

AU - Lee, Cheolkyou

AU - Nagao, Masayuki

AU - Kobayashi, Kazuto

AU - Oakada, Nagaya

AU - Tanaka, Naohiko

AU - Santos Filho, Esmeraldo dos

AU - Sasaki, Hidehiko

AU - Tanaka, Motonao

AU - Yambe, Tomoyuki

N1 - Funding Information: This study was supported by Grants-in-Aid for Scientific Research (Scientific Research (B) 15300178, Scientific Research (B) 15360217) from the Japan Society for the Promotion of Science and Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare for the Research on Advanced Medical Technology (H17-Nano-001).

PY - 2006/12/22

Y1 - 2006/12/22

N2 - We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic speed and attenuation of soft tissues. In the present study, we will propose a new concept ultrasonic speed microscopy that can measure the thickness and ultrasonic speed using fast Fourier transform of a single pulsed wave instead of continuous waves used in conventional SAM systems. Six coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 121 s and two-dimensional distribution of ultrasonic speed was obtained. The ultrasonic speed was 1720 m/s in the thickened intima with collagen fiber, 1520 m/s in lipid deposition underlying fibrous cap and 1830 m/s in calcified lesion in the intima. These basic measurements will help understanding echogenecity in intravascular ultrasound (IVUS) images. Imaging of coronary artery with the ultrasonic speed microscopy provides important information for study of IVUS coronary imaging.

AB - We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic speed and attenuation of soft tissues. In the present study, we will propose a new concept ultrasonic speed microscopy that can measure the thickness and ultrasonic speed using fast Fourier transform of a single pulsed wave instead of continuous waves used in conventional SAM systems. Six coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 121 s and two-dimensional distribution of ultrasonic speed was obtained. The ultrasonic speed was 1720 m/s in the thickened intima with collagen fiber, 1520 m/s in lipid deposition underlying fibrous cap and 1830 m/s in calcified lesion in the intima. These basic measurements will help understanding echogenecity in intravascular ultrasound (IVUS) images. Imaging of coronary artery with the ultrasonic speed microscopy provides important information for study of IVUS coronary imaging.

KW - Acoustic microscopy

KW - Atherosclerosis

KW - Coronary artery

KW - Ultrasonic speed

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Ultrasonic speed microscopy for imaging of coronary artery

Abstract

Keywords

ASJC Scopus subject areas

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