山下 光雄

研究成果

年別の研究成果 1983 1994 2002 2011 2022

• 157 Article
• 4 Chapter
• 3 Review article
• 2 Book
• 3 その他
  • 2 Foreword/postscript
  • 1 Comment/debate

年別の研究成果

年別の研究成果

検索結果

• 2007

  Bacillus selenatarsenatis sp. nov., a selenate- and arsenate-reducing bacterium isolated from the effluent drain of a glass-manufacturing plant

  Yamamura, S., Yamashita, M., Fujimoto, N., Kuroda, M., Kashiwa, M., Sei, K., Fujita, M. & Ike, M., 2007 5月, In: International Journal of Systematic and Evolutionary Microbiology. 57, 5, p. 1060-1064 5 p.

  研究成果: Article › 査読

  • Selenic Acid 100%
  • arsenic acid 89%
  • Manufacturing and Industrial Facilities 84%
  • selenate 84%
  • selenates 81%
  57 被引用数 (Scopus)

• Bioremediation of cadmium contaminated soil using symbiosis between leguminous plant and recombinant rhizobia with the MTL4 and the PCS genes

  Ike, A., Sriprang, R., Ono, H., Murooka, Y. & Yamashita, M., 2007 1月, In: Chemosphere. 66, 9, p. 1670-1676 7 p.

  研究成果: Article › 査読

  • Contaminated soil 100%
  • Bioremediation 91%
  • Rhizobium 86%
  • Environmental Biodegradation 83%
  • Cadmium 77%
  113 被引用数 (Scopus)
• 2006

  Construction of an additional metal-binding site in human metallothionein-2

  Toyama, M., Sasaki, M., Hirayama, N., Murooka, Y. & Yamashita, M., 2006 4月, In: Journal of Bioscience and Bioengineering. 101, 4, p. 354-360 7 p.

  研究成果: Article › 査読

  • Binding sites 100%
  • Metallothionein 88%
  • Mutant Proteins 76%
  • Proteins 65%
  • Metals 61%
  4 被引用数 (Scopus)

• Creation of an additional metal-binding site in human metallothionein-2

  Toyama, T., M., M., Sasaki, S., Hirayama, H., N., N., Murooka, M., Y., Y. & Yamashita, Y., 2006 1月 1, In: J. Biosci. Bioeng..

  研究成果: Article › 査読
• 2005

  ACETIC ACID BACTERIA IN TRADITIONAL JAPANESE RICE VINEGARS

  Murooka, Y., Yamashita, M., Taniguchi, M., N, K., a, A. & Ujike, S., 2005 5月 12, In: Default journal.

  研究成果: Article › 査読

• APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus

  Glasgow, E., Ryu, S. L., Yamashita, M., Zhang, B. J., Mutsuga, N. & Gainer, H., 2005 6月 13, In: Molecular Brain Research. 137, 1-2, p. 143-151 9 p.

  研究成果: Article › 査読

  • Supraoptic Nucleus 100%
  • Antisense RNA 98%
  • Vasopressins 69%
  • Neurons 46%
  • Oxytocin 31%
  8 被引用数 (Scopus)

• BIOREMEDIATION FOR HEAVY METALS THROUGH SYSBIOSIS BETWEEN LEGUMINOUS PLANTS AND RHIZOBIA

  Murooka, Y., Ike, Y. M., Sriprang, R., Yamashita, M., AkikoIke, A. I. & Sriprang, U., 2005 12月 2, In: Default journal.

  研究成果: Article › 査読

• EGFP-tagged vasopressin precursor protein sorting into large dense core vesicles and secretion from PC12 cells

  Zhang, B. J., Yamashita, M., Fields, R., Kusano, K. & Gainer, H., 2005 6月, In: Cellular and Molecular Neurobiology. 25, 3-4, p. 581-605 25 p.

  研究成果: Article › 査読

  • Neurophysins 100%
  • enhanced green fluorescent protein 80%
  • Secretory Vesicles 73%
  • PC12 Cells 73%
  • Protein Transport 71%
  8 被引用数 (Scopus)

• Production of tetrapyrrole compounds and vitamin B₁₂ using genetically engineering of Propionibacterium freudenreichii. An overview

  Murooka, Y., Piao, Y., Kiatpapan, P. & Yamashita, M., 2005 1月, In: Lait. 85, 1-2, p. 9-22 14 p.

  研究成果: Article › 査読

  • Propionibacterium freudenreichii 100%
  • Tetrapyrroles 93%
  • vitamin B12 63%
  • Vitamin B 12 59%
  • engineering 48%
  21 被引用数 (Scopus)
• 2004

  Effect of the Expression of the hemA and hemB Genes on the Production of Porphyrin in Propionibacterium freudenreichii

  Piao, Y., Kiatpapan, P., Yamashita, M. & Murooka, Y., 2004 1月 1, In: Appl. Enviroment. Microbiol..

  研究成果: Article › 査読

• Effects of expression of hemA and hemB genes on production of porphyrin in Propionibacterium freudenreichii

  Piao, Y., Kiatpapan, P., Yamashita, M. & Murooka, Y., 2004 12月, In: Applied and Environmental Microbiology. 70, 12, p. 7561-7566 6 p.

  研究成果: Article › 査読

  • Propionibacterium freudenreichii 100%
  • Tetrapyrroles 93%
  • porphyrin 76%
  • Aminolevulinic Acid 69%
  • Porphyrins 69%
  24 被引用数 (Scopus)

• Production of vitamin B₁₂ in genetically engineered Propionibacterium freudenreichii

  Piao, Y., Yamashita, M., Kawaraichi, N., Asegawa, R., Ono, H. & Murooka, Y., 2004 9月, In: Journal of Bioscience and Bioengineering. 98, 3, p. 167-173 7 p.

  研究成果: Article › 査読

  • Propionibacterium freudenreichii 100%
  • Vitamins 81%
  • Vitamin B 12 59%
  • Vitamin 55%
  • Genes 38%
  76 被引用数 (Scopus)

• Production of Vitamin B12 in Genetically Engineered Propionibacterium freudenreichii

  Piao, Y., Yamashita, M., Kawaraichi, N., Asegawa, R. & Murooka, H. O., 2004 1月 1, In: J. Biosci. Bioeng..

  研究成果: Article › 査読

  75 被引用数 (Scopus)
• 2003

  Production of 5-aminolevulinic acid and vitamin B12 using metabolic engineering of Propionibacterium freudenreichii

  Kiatpapan, P., Karnamnuoy, N., Jonserijit, B., Piao, Y-Z., Yamashita, M. & Murooka, Y., 2003 1月 1, In: ACS symposium series 862. p. 221-232

  研究成果: Article › 査読
• 2002

  Alteration of substrate specificity of cholesterol oxidase from Streptomyces sp. by site-directed mutagenesis

  Toyama, M., Yamashita, M., Yoneda, M., Zaborowski, A., Nagato, M., Ono, H., Hirayama, N. & Murooka, Y., 2002, In: Protein Engineering. 15, 6, p. 477-483 7 p.

  研究成果: Article › 査読

  Open Access

  • Cholesterol Oxidase 100%
  • Mutagenesis 92%
  • Cholesterol 90%
  • Oxidoreductases 88%
  • Streptomyces 72%
  16 被引用数 (Scopus)

• A novel bioremediation system for heavy metals using the symbiosis between leguminous plant and genetically engineered rhizobia

  Sriprang, R., Hayashi, M., Yamashita, M., Ono, H., Saeki, K. & Murooka, Y., 2002 11月 13, In: Journal of Biotechnology. 99, 3, p. 279-293 15 p.

  研究成果: Article › 査読

  • Bioremediation 100%
  • Genetically Modified Plants 97%
  • Rhizobium 94%
  • Environmental Biodegradation 90%
  • Symbiosis 83%
  98 被引用数 (Scopus)

• Bacterium-based heavy metal biosorbents: Enhanced uptake of cadmium by E. coli Expressing a metallothionein fused to β-galactosidase

  Yoshida, N., Kato, T., Yoshida, T., Ogawa, K., Yamashita, M. & Murooka, Y., 2002, In: BioTechniques. 32, 3, p. 551-558 8 p.

  研究成果: Article › 査読

  Open Access

  • Galactosidases 100%
  • Metallothionein 82%
  • Heavy Metals 79%
  • Cadmium 75%
  • Heavy Metal 55%
  15 被引用数 (Scopus)

• Development of xylitol oxidase-based flow injection analysis for monitoring of xylitol concentrations

  Rhee, J. I., Yamashita, M. & Scheper, T., 2002 4月 8, In: Analytica Chimica Acta. 456, 2, p. 293-301 9 p.

  研究成果: Article › 査読

  • Flow Injection Analysis 100%
  • Xylitol 78%
  • Oxidoreductases 49%
  • monitoring 28%
  • matrix 21%
  6 被引用数 (Scopus)

• Escherichia coli cells penetrated by chrysotile fibers are transformed to antibiotic resistance by incorporation of exogenous plasmid DNA

  Yoshida, N., Kodama, K., Nakata, K., Yamashita, M. & Miwa, T., 2002 12月, In: Applied Microbiology and Biotechnology. 60, 4, p. 461-468 8 p.

  研究成果: Article › 査読

  • Serpentine Asbestos 100%
  • Microbial Drug Resistance 67%
  • Plasmids 54%
  • Escherichia coli 47%
  • DNA 37%
  16 被引用数 (Scopus)

• Identification of cell-specific messenger ribonucleic acids in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization

  Yamashita, M., Glasgow, E., Zhang, B. J., Kusano, K. & Gainer, H., 2002 11月 1, In: Endocrinology. 143, 11, p. 4464-4476 13 p.

  研究成果: Article › 査読

  Open Access

  • Supraoptic Nucleus 100%
  • Oxytocin 71%
  • Vasopressins 68%
  • RNA 52%
  • Neurons 46%
  17 被引用数 (Scopus)

• Identification of cell-specific mRNAs in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization

  Yamashita, M., Glasgow, E., Zhang, B-J., Kusano, K. & Gainer, H., 2002 1月 1, In: Endocrinology.

  研究成果: Article › 査読

• Interactions of arsenic with human metallothionein-2

  Toyama, M., Yamashita, M., Hirayama, N. & Murooka, Y., 2002 8月, In: Journal of biochemistry. 132, 2, p. 217-221 5 p.

  研究成果: Article › 査読

  • Metallothionein 100%
  • Arsenic 96%
  • Time-of-Flight Mass Spectrometry 60%
  • Plasma Atomic Emission Spectroscopy 44%
  • UV Absorption 43%
  43 被引用数 (Scopus)

• Interactions of arsenic with human metallothionein-2

  Toyama, T., M., M., Yamashita, Y., M, M., Hirayama, H., N., N., Murooka, M. & Y., Y., 2002 1月 1, In: J. Biochem..

  研究成果: Article › 査読

  43 被引用数 (Scopus)

• The magnocellular neuronal phenotype: Cell-specific gene expression in the hypothalamo-neurohypophysial system

  Gainer, H., Yamashita, M., Fields, R. L., House, S. B. & Rusnak, M., 2002, In: Progress in Brain Research. 139, p. 1-14 14 p.

  研究成果: Article › 査読

  • Intergenic DNA 100%
  • Phenotype 58%
  • Gene Expression 58%
  • Oxytocin 42%
  • Vasopressins 40%
  24 被引用数 (Scopus)
• 2001

  An efficient gene expression system in propionibacteria and its use in production of 5-aminolevulinic acid (ALA).

  Kiatpapan, P., Kawaraichi, N., Yamashita, M. & Murooka, Y., 2001 7月 1, In: Default journal.

  研究成果: Article › 査読

• Engineered Streptomyces cholesterol oxidase and its application

  Murooka, Y., Toyama, M., Yamashita, M. & Hirayama, N., 2001 11月 1, In: Default journal.

  研究成果: Article › 査読

• Expression of the engineered metallothionein gene in nodules of Astragalus sinicus with promoters from the symbiotic plasmid

  Sriprang, R., Hayashi, M., Yamashita, M., Ono, H. & Murooka, Y., 2001 11月 10, In: Default journal.

  研究成果: Article › 査読

• Genetic design of stable metal-binding biomolecules, oligomeric metallothioneins

  Murooka, Y., Toyama, M., Hong, S. H., Gohya, M., Ono, H., Yamashita, M. & Hirayama, N., 2001, In: Biocatalysis and Biotransformation. 19, 5-6, p. 399-412 14 p.

  研究成果: Article › 査読

  • Biomolecules 100%
  • Metallothionein 88%
  • Escherichia coli 67%
  • Proteins 65%
  • Metals 61%
  4 被引用数 (Scopus)

• Heterologous expression of a gene encoding cholesterol oxidase in probiotic strains of Lactobacillus plantarum and Propionibacterium freudenreichii under the control of native promoters

  Kiatpapan, P., Yamashita, M., Kawaraichi, N., Yasuda, T. & Murooka, Y., 2001, In: Journal of Bioscience and Bioengineering. 92, 5, p. 459-465 7 p.

  研究成果: Article › 査読

  • Probiotics 100%
  • Propionibacterium freudenreichii 99%
  • Gene encoding 98%
  • Cholesterol Oxidase 92%
  • Cholesterol 83%
  23 被引用数 (Scopus)

• Molecular characterization of Lactobacillus plantarum genes for β-ketoacyl-acyl carrier protein synthase III (fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesis

  Kiatpapan, P., Kobayashi, H., Sakaguchi, M., Ono, H., Yamashita, M., Kaneko, Y. & Murooka, Y., 2001, In: Applied and Environmental Microbiology. 67, 1, p. 426-433 8 p.

  研究成果: Article › 査読

  • holo-(acyl-carrier-protein) synthase 100%
  • Lactobacillus plantarum 73%
  • Acetyl-CoA Carboxylase 72%
  • acyl carrier protein 71%
  • Essential Fatty Acids 70%
  10 被引用数 (Scopus)

• Molecular design of oligomeric metallothionein and its use in bioremediation for soils polluted with heavy metals

  Murooka, Y., Toyama, M., Hayashi, M. & Yamashita, M., 2001 7月 1, In: Default journal.

  研究成果: Article › 査読
• 2000

  Bioremidiation system for heavy metals using leguminous plant and Rhizobia symbiosis

  Rutchadaporn, S., Yano, K., Hayashi, M., Yamashita, M. & Murooka, Y., 2000 8月 3, In: Default journal.

  研究成果: Article › 査読

• Characterization of pRGO1, a plasmid from Propionibacterium acidipropionici, and its use for development of a host-vector system in propionibacteria

  Kiatpapan, P., Hashimoto, Y., Nakamura, H., Piao, Y. Z., Ono, H., Yamashita, M. & Murooka, Y., 2000, In: Applied and Environmental Microbiology. 66, 11, p. 4688-4695 8 p.

  研究成果: Article › 査読

  • Propionibacterium freudenreichii 100%
  • Propionibacterium acidipropionici 88%
  • Propionibacterium 82%
  • plasmid 65%
  • Propionibacterium freudenreichii subsp. shermanii 58%
  26 被引用数 (Scopus)

• Improvement of a diagnostic enzyme, Streptomyces cholesterol oxidase, by site-directed mutagenesis

  Yamashita, M., Toyama, M., Aoike, M., Yoneda, M., Zaborowski, A., Ono, H. & Murooka, Y., 2000 11月 1, In: Default journal.

  研究成果: Article › 査読

• Isolation, characterization, and molecular cloning of a thermostable xylitol oxidase from Streptomyces sp. IKD472

  Yamashita, M., Omura, H., Okamoto, E., Furuya, Y., Yabuuchi, M., Fukahi, K. & Murooka, Y., 2000, In: Journal of Bioscience and Bioengineering. 89, 4, p. 350-360 11 p.

  研究成果: Article › 査読

  • Oxidoreductases 100%
  • Xylitol 96%
  • Cloning 88%
  • Streptomyces 81%
  • Molecular Cloning 76%
  10 被引用数 (Scopus)

• Molecular design of novel metal-binding oligomeric human metallothioneins

  Hong, S. H., Gohya, M., Ono, H., Murakami, H., Yamashita, M., Hirayama, N. & Murooka, Y., 2000, In: Applied Microbiology and Biotechnology. 54, 1, p. 84-89 6 p.

  研究成果: Article › 査読

  • Metallothionein 100%
  • Metals 69%
  • glycyl-glycyl-glycine 16%
  • Ions 14%
  • Proteins 13%
  9 被引用数 (Scopus)

• Site directed mutagenesis the cholesterol oxidase gene from Streptomyces

  Zaborowski, A., Toyama, M., Yamashita, M. & Murooka, Y., 2000 8月 3, In: Default journal.

  研究成果: Article › 査読
• 1999

  Cell-specific gene expression In magnocellular Oxytocin and Vasopressin neurons In Rat Hypothalamus: A differential Hybridization Screening Strategy

  Yamashita, Y., M., M., Zhang, Z., B., B., Glasgow, G., E., E., Kusano, K., K., K., Gainer, G. & H., H., 1999 10月 28, In: Default journal.

  研究成果: Article › 査読

• Differential gene expression in magnocellular Oxytocin and Vasopressin neurons in Rat Hypothalamus

  Yamashita, Y., M., M., Glasgow, G., E., E., Kusano, K., K., K., Zhang, Z., B., B. & H., G., 1999 4月 17, In: Default journal.

  研究成果: Article › 査読

• Protein engineering of a multi-functional enzyme, cholesteroloxidase

  Murooka, Y., Nishiya, Y., Yamashita, M. & Hirayama, N., 1999 6月 1, In: Default journal.

  研究成果: Article › 査読

• Sorting and Packaging of Vasopressin-Neurophysin-EGFP Fusion Proteins Into large dense core vesicles (LDCVs) In PC12 cells

  Zhang, Z., B., B., Yamashita, Y., M., M., Fields, F., R., R., Kusano, K., K., K., Tao-Cheng, T-C., J.-H., J-H., Gainer, G. & H., H., 1999 10月 28, In: Default journal.

  研究成果: Article › 査読

• Studies on the improvement of functions of useful proteins

  Yamashita, M., 1999, In: Seibutsu-kogaku Kaishi. 77, 8, p. 345-357 13 p.

  研究成果: Article › 査読

  • Enzymes 100%
  • enzymes 81%
  • protein engineering 67%
  • Proteins 67%
  • Protein Engineering 62%
• 1998

  Analysis of differential gene expression in magnocellular Oxytocin and Vasopressin neurons.

  Glasgow, G., E., E., Yamashita, Y., M., M., Kusano, K., K., K., Chin, C., H., H. & Gainer, G., 1998 11月 7, In: Default journal.

  研究成果: Article › 査読

• Cloning, Sequencing and Characterisation of a Downstream Region of ksdDI Operon of Arthrobacter simplex

  Dziadek, J., Yamashita, M. & Murooka, Y., 1998 12月 1, In: Acta Microbiologica Polonica. 47, 4, p. 345-353 9 p.

  研究成果: Article › 査読

  • Ketosteroids 100%
  • Arthrobacter 94%
  • Operon 66%
  • Organism Cloning 55%
  • Oxidoreductases 44%
  2 被引用数 (Scopus)

• Cyclic AMP regulation of the mob operon of the non-self-transmissible plasmid pEC3 isolated from a phytopathogenic bacterium

  Nomura, N., Yamashita, M. & Murooka, Y., 1998, In: Journal of Fermentation and Bioengineering. 86, 6, p. 534-538 5 p.

  研究成果: Article › 査読

  • Operon 100%
  • Cyclic AMP 89%
  • Plasmids 73%
  • Bacteria 61%
  • Pectobacterium carotovorum 52%
  1 被引用数 (Scopus)

• Effect of non-ionic detergents on apparent enzyme mechanism: V121A mutant of Streptomyces cholesterol oxidase endowed with enhanced sensitivity towards detergents

  Nishiya, Y., Yamashita, M., Murooka, Y., Fujii, I. & Hirayama, N., 1998 8月, In: Protein Engineering. 11, 8, p. 609-611 3 p.

  研究成果: Article › 査読

  Open Access

  • Cholesterol Oxidase 100%
  • Cholesterol 90%
  • Oxidoreductases 88%
  • Detergents 80%
  • Streptomyces 72%
  7 被引用数 (Scopus)

• Effect of non-ionic detergents on apparent enzyme mechanism: V121A mutant of Streptomyces cholesterol oxidase endowed with enhanced sensitivity towards detergents

  Nishiya, N., Y., Y., Yamashita, Y., M, M., Murooka, M., Fujii, F., I, I., Hirayama, H. & N., N., 1998 1月 1, In: Protein Eng..

  研究成果: Article › 査読

  10 被引用数 (Scopus)

• Heavy metal-binding protein from Thiobacillus intermedius and adsorption of the cells to crystal particles of heavy metals

  Yoshida, Y., N., N., Murooka, M., Y., Y., Yamashita, Y., M., M. & T., M., 1998 1月 1, In: Recent Res. Devel. in Fermentation & Bioeng..

  研究成果: Article › 査読

• Improvement of thermal stability of a diagnostic enzyme, Streptomyces cholesterol oxidase, by random and site-directed mutagenesis and a structural interpretation

  Murooka, Y., Nishiya, Y., Toyama, M., Aoike, M., Yamashita, M. & Hirayama, N., 1998 4月 20, In: Default journal.

  研究成果: Article › 査読

• Separation of the two reactions, oxidation and isomerization, catalyzed by Streptomyces cholesterol oxidase

  Yamashita, M., Toyama, M., Ono, H., Fujii, I., Hirayama, N. & Murooka, Y., 1998 11月, In: Protein Engineering. 11, 11, p. 1075-1081 7 p.

  研究成果: Article › 査読

  • Cholesterol Oxidase 100%
  • Cholesterol 90%
  • Oxidoreductases 88%
  • Isomerization 84%
  • Streptomyces 72%
  39 被引用数 (Scopus)