TY - JOUR
T1 - Age-related changes in the numbers of mammotrophs, somatotrophs and mammosomatotrophs in the anterior pituitary gland of female rats
T2 - A flow cytometric study
AU - Shinkai, Tadashi
AU - Sakurai, Yoko
AU - Ooka, Hiroshi
PY - 1995/9/15
Y1 - 1995/9/15
N2 - Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.
AB - Age-related changes in the numbers of mammotrophs, somatotrophs, mammosomatotrophs, and the cells of other types in the anterior pituitary of female Wistar rat were measured by flow cytometry. The mammotrophs increased with age, and the somatotrophs decreased with senescence. The mammosomatotrophs increased remarkably in senescent rats, and these cells of the rats older than 21 months were about 10 times more than those of 3, and 12-13 months old rats. This result indicates that the stability of gene expression in cell differentiation is reduced in the aging process of the anterior pituitary.
KW - Acidophils
KW - Aging
KW - Flow cytometry
KW - Mammosomatotroph
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0028789414&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028789414&partnerID=8YFLogxK
U2 - 10.1016/0047-6374(95)01614-6
DO - 10.1016/0047-6374(95)01614-6
M3 - Article
C2 - 8583831
AN - SCOPUS:0028789414
SN - 0047-6374
VL - 83
SP - 125
EP - 131
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 3
ER -