TY - GEN

T1 - Analysis for nonlinear inversion technique developed to estimate depth-distribution of absorption by spatially resolved backscattering measurement

AU - Nishida, Kazuhiro

AU - Namita, Takeshi

AU - Kato, Yuji

AU - Shimizu, Koichi

N1 - Publisher Copyright:
© 2015 SPIE.

PY - 2015

Y1 - 2015

N2 - We have proposed a new nonlinear inversion technique to estimate the spatial distribution of the absorption coefficient (μa) in the depth direction of a turbid medium by spatially resolved backscattering measurement. With this technique, we can obtain cross-sectional image of μa as deep as the backscattered light traveled even when the transmitted light through the medium cannot be detected. In this technique, the depth distribution of absorption coefficient is determined by iterative calculation using the spatial path-length distribution (SPD) of traveled photons as a function of source-detector distance. In this calculation, the variance of path-length of many photons in each layer is also required. The SPD and the variance of path-length are obtained by Monte Carlo simulation using a known reduced scattering coefficient (μs€™). Therefore, we need to know the μs€™ of the turbid medium beforehand. We have shown in computer simulation that this technique works well when the μs€™ is the typical values of mammalian body tissue, or 1.0 /mm. In this study, the accuracy of the μa estimation was analyzed and its dependence on the μs€™ was clarified quantitatively in various situations expected in practice. 10% deviations in μs€™ resulted in about 30% error in μa estimation, in average. This suggested that the measurement or the appropriate estimation of μs€™ is required to utilize the proposed technique effectively. Through this analysis, the effectiveness and the limitation of the newly proposed technique were clarified, and the problems to be solved were identified.

AB - We have proposed a new nonlinear inversion technique to estimate the spatial distribution of the absorption coefficient (μa) in the depth direction of a turbid medium by spatially resolved backscattering measurement. With this technique, we can obtain cross-sectional image of μa as deep as the backscattered light traveled even when the transmitted light through the medium cannot be detected. In this technique, the depth distribution of absorption coefficient is determined by iterative calculation using the spatial path-length distribution (SPD) of traveled photons as a function of source-detector distance. In this calculation, the variance of path-length of many photons in each layer is also required. The SPD and the variance of path-length are obtained by Monte Carlo simulation using a known reduced scattering coefficient (μs€™). Therefore, we need to know the μs€™ of the turbid medium beforehand. We have shown in computer simulation that this technique works well when the μs€™ is the typical values of mammalian body tissue, or 1.0 /mm. In this study, the accuracy of the μa estimation was analyzed and its dependence on the μs€™ was clarified quantitatively in various situations expected in practice. 10% deviations in μs€™ resulted in about 30% error in μa estimation, in average. This suggested that the measurement or the appropriate estimation of μs€™ is required to utilize the proposed technique effectively. Through this analysis, the effectiveness and the limitation of the newly proposed technique were clarified, and the problems to be solved were identified.

KW - Absorption coefficient

KW - Backscattering

KW - Biomedical optics

KW - CT imaging

KW - Nonlinear inversion technique

KW - Reduced scattering coefficient

KW - Space-resolved measurement

UR - http://www.scopus.com/inward/record.url?scp=84928721818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928721818&partnerID=8YFLogxK

U2 - 10.1117/12.2078168

DO - 10.1117/12.2078168

M3 - Conference contribution

AN - SCOPUS:84928721818

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Tomography and Spectroscopy of Tissue XI

A2 - Alfano, Robert R.

A2 - Sevick-Muraca, Eva M.

A2 - Tromberg, Bruce J.

A2 - Yodh, Arjun G.

PB - SPIE

T2 - Optical Tomography and Spectroscopy of Tissue XI

Y2 - 9 February 2015 through 11 February 2015

ER -