Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

Hitoshi Asakura; Masaharu Tsuchiya; Sadakazu Aiso; Mamoru Watanabe; Kensuke Kobayashi; Toshifumi Hibi; Koshi Ando; Hajime Takata; Susumu Sekiguchi

doi:10.1016/S0016-5085(82)80387-9

Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

Hitoshi Asakura, Masaharu Tsuchiya, Sadakazu Aiso, Mamoru Watanabe, Kensuke Kobayashi, Toshifumi Hibi, Koshi Ando, Hajime Takata, Susumu Sekiguchi

研究成果: Article › 査読

153 被引用数 (Scopus)

抄録

The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ² = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ² = 10.84, p < 0.001).

本文言語	English
ページ（範囲）	413-418
ページ数	6
ジャーナル	Gastroenterology
巻	82
号	3
DOI	https://doi.org/10.1016/S0016-5085(82)80387-9
出版ステータス	Published - 1982
外部発表	はい

ASJC Scopus subject areas

肝臓学
消化器病学

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10.1016/S0016-5085(82)80387-9

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title = "Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis",

abstract = "The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).",

author = "Hitoshi Asakura and Masaharu Tsuchiya and Sadakazu Aiso and Mamoru Watanabe and Kensuke Kobayashi and Toshifumi Hibi and Koshi Ando and Hajime Takata and Susumu Sekiguchi",

year = "1982",

doi = "10.1016/S0016-5085(82)80387-9",

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T1 - Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

AU - Asakura, Hitoshi

AU - Tsuchiya, Masaharu

AU - Aiso, Sadakazu

AU - Watanabe, Mamoru

AU - Kobayashi, Kensuke

AU - Hibi, Toshifumi

AU - Ando, Koshi

AU - Takata, Hajime

AU - Sekiguchi, Susumu

PY - 1982

Y1 - 1982

N2 - The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).

AB - The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).

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Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

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