TY - JOUR
T1 - Catalytic Enantioselective Synthesis of N-C Axially Chiral Sulfonamides through Chiral Palladium-Catalyzed N-Allylation
AU - Kikuchi, Yuki
AU - Nakamura, Chisato
AU - Matsuoka, Mizuki
AU - Asami, Rina
AU - Kitagawa, Osamu
N1 - Funding Information:
This work was partly supported by JSPS KAKENNHI (C 17K08220).
Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/6/21
Y1 - 2019/6/21
N2 - In the presence of (S,S)-Trost ligand and (allyl-Pd-Cl)2 catalyst, the reaction of allyl acetate with the anionic species prepared from various N-(2-tert-butylphenyl)sulfonamides and NaH proceeded in an enantioselective manner (up to 95% ee) to give optically active N-allylated sulfonamide derivatives possessing an N-C axially chiral structure in high yields.
AB - In the presence of (S,S)-Trost ligand and (allyl-Pd-Cl)2 catalyst, the reaction of allyl acetate with the anionic species prepared from various N-(2-tert-butylphenyl)sulfonamides and NaH proceeded in an enantioselective manner (up to 95% ee) to give optically active N-allylated sulfonamide derivatives possessing an N-C axially chiral structure in high yields.
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U2 - 10.1021/acs.joc.9b00989
DO - 10.1021/acs.joc.9b00989
M3 - Article
C2 - 31117580
AN - SCOPUS:85067005782
SN - 0022-3263
VL - 84
SP - 8112
EP - 8120
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 12
ER -