TY - JOUR
T1 - Cloning and expression of a human/mouse polycomb group gene, ENX-2/Enx- 2
AU - Ogawa, Motoyuki
AU - Hiraoka, Yoshiki
AU - Taniguchi, Koji
AU - Aiso, Sadakazu
N1 - Funding Information:
We thank Dr. H. Ikeshima for her gift of the mouse cDNA library, and Drs. J. Hata and A. Umezawa for their generous gift of the RNA samples of NCR-G3 cell. This work was supported in part by grants from Ministry of Education, Science and Culture to S.A. and Y.H., and by Keio Gakuji Fukuzawa Memorial Funds for the Advancement of Education and Research and Keio Gakuji Academic Developmental Funds from Keio University to S.A., Y.H and M.O.
PY - 1998/1/21
Y1 - 1998/1/21
N2 - The Drosophila Polycomb group (Pc-G) genes encode transcriptional factors involved in development. Little is known about members of the vertebrate Pc-G genes. In this study, we have isolated a cDNA encoding a human Pc-G protein and the mouse equivalent. The human and mouse genes, which were named ENX-2 and Enx-2, encode 702 and 750 amino acids, respectively. ENX-2/Enx-2 protein exhibits a high homology (53-55% identity) to Drosophila Enhancer of zeste [E(z)] protein belonging to the Pc-G. The expression of Enx-2 was observed in mouse kidney, adrenal gland, testis and brain at high levels by Northern blot analysis. A cell line of mouse neuroblastoma, Neuro- 2a, also expresses Enx-2 mRNA and its level is elevated by induction of neuronal differentiation of the cell.
AB - The Drosophila Polycomb group (Pc-G) genes encode transcriptional factors involved in development. Little is known about members of the vertebrate Pc-G genes. In this study, we have isolated a cDNA encoding a human Pc-G protein and the mouse equivalent. The human and mouse genes, which were named ENX-2 and Enx-2, encode 702 and 750 amino acids, respectively. ENX-2/Enx-2 protein exhibits a high homology (53-55% identity) to Drosophila Enhancer of zeste [E(z)] protein belonging to the Pc-G. The expression of Enx-2 was observed in mouse kidney, adrenal gland, testis and brain at high levels by Northern blot analysis. A cell line of mouse neuroblastoma, Neuro- 2a, also expresses Enx-2 mRNA and its level is elevated by induction of neuronal differentiation of the cell.
KW - Development
KW - Enhancer of zeste
KW - Hematopoietic cell
KW - Neuro-2a
KW - Neuronal differentiation
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U2 - 10.1016/S0167-4781(97)00156-5
DO - 10.1016/S0167-4781(97)00156-5
M3 - Article
C2 - 9473645
AN - SCOPUS:0032554079
SN - 0167-4781
VL - 1395
SP - 151
EP - 158
JO - Biochimica et Biophysica Acta - Gene Structure and Expression
JF - Biochimica et Biophysica Acta - Gene Structure and Expression
IS - 2
ER -