@article{ecc8edcc973b46c88be57b3a154a5275,
title = "Detection of Isotopic Atropisomerism Based on ortho-H/D Discrimination",
abstract = "Racemic and optically active 3-(2-deuteriophenyl)-2-(1-phenylpropan-2-yl)quinazoline-4-thiones were prepared. The nuclear magnetic resonance spectra clearly show that they exist as a 1:1 mixture of diastereomers due to the isotopic atropisomerism based on ortho-H/D discrimination (N-C axial chirality) and a chiral carbon.",
author = "Kazuya Saito and Shota Miwa and Asumi Iida and Yuuki Fujimoto and Elsa Caytan and Christian Roussel and Osamu Kitagawa",
note = "Funding Information: We thank the Daicel Corporation for the support of the chiral HPLC separation attempts of rac- 4 . This work was partially supported by JSPS KAKENHI (C 20K06945). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = oct,
day = "1",
doi = "10.1021/acs.orglett.1c02723",
language = "English",
volume = "23",
pages = "7492--7496",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "19",
}