TY - JOUR
T1 - Effects of chronic hyperthyroidism on the lifespan of the rat
AU - Ooka, Hiroshi
AU - Shinkai, Tadashi
PY - 1986/2
Y1 - 1986/2
N2 - The life durations of hypo- and hyperthyroid Wistar rats were measured under clean conventional conditions. The amount of exogenous T4 (thyroxine), which is sufficient to elevate T4 levels in the blood, decreased with age. The rats which were made hypothyroid by the neonatal T4 treatment had a longer lifespan than control. The lifespans of hyperthyroid rats, to which T4 solutions were given as drinking water during either the first or the second half of the life period, were shorter than control. The life-shortening effect of T4 was not detected when T4 was administered to already aged animals. These results indicate that the effect of T4 administration is not due to the direct promotion of the diseases which cause the death, but to the acceleration of aging during the young or middle-aged period.
AB - The life durations of hypo- and hyperthyroid Wistar rats were measured under clean conventional conditions. The amount of exogenous T4 (thyroxine), which is sufficient to elevate T4 levels in the blood, decreased with age. The rats which were made hypothyroid by the neonatal T4 treatment had a longer lifespan than control. The lifespans of hyperthyroid rats, to which T4 solutions were given as drinking water during either the first or the second half of the life period, were shorter than control. The life-shortening effect of T4 was not detected when T4 was administered to already aged animals. These results indicate that the effect of T4 administration is not due to the direct promotion of the diseases which cause the death, but to the acceleration of aging during the young or middle-aged period.
KW - Hyperthyroidism
KW - Lifespan
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0022627814&partnerID=8YFLogxK
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U2 - 10.1016/0047-6374(86)90052-7
DO - 10.1016/0047-6374(86)90052-7
M3 - Article
C2 - 3713266
AN - SCOPUS:0022627814
SN - 0047-6374
VL - 33
SP - 275
EP - 282
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
IS - 3
ER -