@article{91f358b0ecb043969292a4fc398d409d,
title = "Efficient synthesis and biological evaluation of ω-oxygenated analogues of vitamin K2: Study of modification and structure-activity relationship of vitamin K2 metabolites",
abstract = "Novel ω-oxygenated vitamin K2 analogues, which are candidates for metabolites of vitamin K2 homologues, were efficiently synthesized and their apoptosis-inducing activity was evaluated. We revealed that some of those analogues were biologically active and the side-chain part played an important role in apoptosis-inducing activity. Our results can provide useful information to develop the structure-activity relationship of vitamin K2 analogues for new drugs based on vitamin K.",
keywords = "Analogue, Apoptosis, Menaquinone-4, Metabolite, Vitamin K",
author = "Yoshitomo Suhara and Aya Murakami and Maya Kamao and Shino Mimatsu and Kimie Nakagawa and Naoko Tsugawa and Toshio Okano",
note = "Funding Information: We are grateful to Dr. Makiko Sugiura and Dr. Atsuko Takeuchi for the spectroscopic measurements. We are also grateful to Eisai Co., Ltd. for the gift of vitamin K standards. This study was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. ",
year = "2007",
month = mar,
day = "15",
doi = "10.1016/j.bmcl.2006.12.082",
language = "English",
volume = "17",
pages = "1622--1625",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "6",
}