Glucose driven drug release system using improved decompression unit

Daisuke Mori, Koji Kurihara, Munkhjargal Munkhbayar, Koji Toma, Takahiro Arakawa, Kazuyoshi Yano, Kohji Mitsubayashi

研究成果: Article査読


In this work, an enhanced performance of an enzymatic chemo-mechanical actuator that can convert the chemical energy of glucose into mechanical energy for autonomous drug release without an electrical power is reported. The novel biochemical approach is based on increasing the decompression rate in a "vacuum unit" by fabricating enzyme co-immobilized membrane by multiple enzymes. Among the enzymes (glucose oxidase (GOD), pyranose oxidase (POD), alcohol oxidase (AOD)), which can oxidize glucose and/or glucono-1.5-lactone evaluated in co-immobilization designs within the vacuum unit, the highest decompression was obtained with POD+GOD, which was 3 times higher than that of the conventional organic engine with only GOD. Furthermore, the decompression rate of -7.4 Pa·cm3/sec in the vacuum unit necessary to drive the drug release system was obtained at 10 mmol/L glucose, which is close to the human blood sugar level. In conclusion, the vacuum unit is a promising device for development of a chemomechanical system driven by human blood sugar for the diabetes treatment.

ジャーナルIEEJ Transactions on Sensors and Micromachines
出版ステータスPublished - 2017

ASJC Scopus subject areas

  • 機械工学
  • 電子工学および電気工学


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