TY - JOUR
T1 - Grapefruit Oil and Cobalt Nitrate-Loaded Polyurethane Hybrid Nanofibrous Scaffold for Biomedical Applications
AU - Mani, Mohan Prasath
AU - Mohd Faudzi, Ahmad Athif
AU - Mohamaddan, Shahrol
AU - Ismail, Ahmad Fauzi
AU - Rathanasamy, Rajasekar
AU - Ayyar, Manikandan
AU - Jaganathan, Saravana Kumar
N1 - Publisher Copyright:
Copyright © 2022 Mani, Mohd Faudzi, Mohamaddan, Ismail, Rathanasamy, Ayyar and Jaganathan.
PY - 2022/3/9
Y1 - 2022/3/9
N2 - The goal of this work is to fabricate a new composite based on polyurethane (PU), grapefruit (GP) oil, and cobalt nitrate [Co(NO3)2] using an electrospinning technique. Morphology results revealed the reduction in the fiber diameter of the composites compared to pristine PU control. The interaction of PU with GP and Co(NO3)2 was confirmed by hydrogen bond formation evident in infrared analysis. The fabricated PU/GP composites depicted a more hydrophobic behavior, while PU/GP/Co(NO3)2 showed a hydrophilic behavior than the pristine PU. Atomic force micrographs (AFM) revealed that the developed composites showed a decrease in the surface roughness (Ra) compared to PU. The addition of GP and Co(NO3)2 improved the mechanical strength of the pristine PU. The blood compatibility assays concluded not only the increase in blood clotting levels but also the less toxic nature of the fabricated composites compared to the pristine PU. Hence, the newly designed composites possessing outstanding physicochemical and biological properties may be used as a potential candidate for scaffolding in tissue engineering applications.
AB - The goal of this work is to fabricate a new composite based on polyurethane (PU), grapefruit (GP) oil, and cobalt nitrate [Co(NO3)2] using an electrospinning technique. Morphology results revealed the reduction in the fiber diameter of the composites compared to pristine PU control. The interaction of PU with GP and Co(NO3)2 was confirmed by hydrogen bond formation evident in infrared analysis. The fabricated PU/GP composites depicted a more hydrophobic behavior, while PU/GP/Co(NO3)2 showed a hydrophilic behavior than the pristine PU. Atomic force micrographs (AFM) revealed that the developed composites showed a decrease in the surface roughness (Ra) compared to PU. The addition of GP and Co(NO3)2 improved the mechanical strength of the pristine PU. The blood compatibility assays concluded not only the increase in blood clotting levels but also the less toxic nature of the fabricated composites compared to the pristine PU. Hence, the newly designed composites possessing outstanding physicochemical and biological properties may be used as a potential candidate for scaffolding in tissue engineering applications.
KW - Co(NO3)2
KW - PU
KW - electrospun scaffold
KW - grapefruit oil
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85127344753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127344753&partnerID=8YFLogxK
U2 - 10.3389/fmats.2022.827009
DO - 10.3389/fmats.2022.827009
M3 - Article
AN - SCOPUS:85127344753
SN - 2296-8016
VL - 9
JO - Frontiers in Materials
JF - Frontiers in Materials
M1 - 827009
ER -