HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Ichiro Kumagai; Tsuyoshi Takahashi; Keita Hamasaki; Akihiko Ueno; Hisakazu Mihara

doi:10.1016/S0960-894X(01)00169-X

HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

Ichiro Kumagai, Tsuyoshi Takahashi, Keita Hamasaki, Akihiko Ueno, Hisakazu Mihara

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

HIV Rev peptides conjugated with peptide nucleic acids (PNAs) were designed and synthesized to develop a designing approach for a novel RNA-binding molecule. The binding affinities of PNA-peptides with the Rev responsive element (RRE) RNA were determined by the competition assay using a rhodamine-labeled Rev. The peptide conjugated with an antisense PNA (TGCGC) bound RRE RNA more efficiently than the molecule without the PNA or the peptide sequence.

本文言語	English
ページ（範囲）	1169-1172
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	11
号	9
DOI	https://doi.org/10.1016/S0960-894X(01)00169-X
出版ステータス	Published - 2001 5月 7
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/S0960-894X(01)00169-X

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AU - Mihara, Hisakazu

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HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA

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