TY - GEN
T1 - Microfluidic long-term cell culture platform with cell-cell interaction monitoring using surface acoustic wave
AU - Takano, Atsushi
AU - Kon, Tasuku
AU - Furuya, Yasubumi
AU - Mochitate, Katsumi
AU - Tanaka, Masato
AU - Futai, Nobuyuki
PY - 2013
Y1 - 2013
N2 - We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).
AB - We have developed a poly(dimethylsiloxane) (PDMS)-made microfluidic long-term cell culture platform having two cell culture wells with piezoelectric substrate bottom on which shear horizontal surface acoustic wave (SH-SAW) propagates. The SH-SAW propagates on the cells could be used to assay cell-cell and/or cell-surface interaction. The platform also enables optical observation of the cells and acquisition of SH-SAW signals simultaneously. The combination of the on-chip CO2 incubation and SH-SAW-based cell monitoring system successfully detected a long-term change in cell-cell or cell-substrate interaction induced by hydrogen peroxide (H2O2).
UR - http://www.scopus.com/inward/record.url?scp=84893738974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893738974&partnerID=8YFLogxK
U2 - 10.1109/MHS.2013.6710472
DO - 10.1109/MHS.2013.6710472
M3 - Conference contribution
AN - SCOPUS:84893738974
SN - 9781479915293
T3 - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
BT - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PB - IEEE Computer Society
T2 - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Y2 - 10 November 2013 through 13 November 2013
ER -