TY - JOUR
T1 - Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.
AU - Watanabe, Kenatarou
AU - Katou, Toyofusa
AU - Ikezawa, Yasunori
AU - Yajima, Saki
AU - Shionoya, Hirohito
AU - Akagi, Takashi
AU - Hamasaki, Keita
PY - 2007
Y1 - 2007
N2 - Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.
AB - Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.
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U2 - 10.1093/nass/nrm105
DO - 10.1093/nass/nrm105
M3 - Article
C2 - 18029660
AN - SCOPUS:42949111188
SN - 1746-8272
SP - 209
EP - 210
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
IS - 51
ER -