TY - JOUR
T1 - Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent
AU - Kono, Takahiro
AU - Imanishi, Nobuaki
AU - Nozawa, Keiko
AU - Takashima, Atsuo
AU - Maheswari, Rajagopalan Uma
AU - Gonome, Hiroki
AU - Yamada, Jun
N1 - Publisher Copyright:
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.
AB - The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5–2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9–76.5% of that of normal skin.
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U2 - 10.1364/BOE.10.003747
DO - 10.1364/BOE.10.003747
M3 - Article
AN - SCOPUS:85070830459
SN - 2156-7085
VL - 10
SP - 3747
EP - 3759
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 8
M1 - 366571
ER -